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Literature summary for 2.3.1.87 extracted from

  • Namboodiri, M.A.A.; Dubbels, R.; Klein, D.C.
    Arylalkylamine N-acetyltransferase from mammalian pineal gland (1987), Methods Enzymol., 142, 583-590.
    View publication on PubMed
Search for more literature for 2.3.1.87

General Stability

General Stability Organism
acetyl-CoA stabilizes Rattus norvegicus
acetyl-CoA stabilizes Ovis aries
ATP stabilizes Rattus norvegicus
ATP stabilizes Ovis aries
freezing markedly decreases activity Rattus norvegicus
freezing markedly decreases activity Ovis aries
polyanions stabilize Rattus norvegicus
polyanions stabilize Ovis aries

Inhibitors

Inhibitors Comment Organism Structure
Disulfides in vivo and in vitro, reversible by dithiothreitol Ovis aries
Disulfides in vivo and in vitro, reversible by dithiothreitol Rattus norvegicus
Peptides containing a disulfide bond
-
 Ovis aries
Peptides containing a disulfide bond
-
 Rattus norvegicus
Zn2+ at low concentration Ovis aries
Zn2+ at low concentration Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information activation by salts as a function of ionic strength Rattus norvegicus
additional information activation by salts as a function of ionic strength Ovis aries

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
-
 Rattus norvegicus
additional information
-
 multiple forms, from 10000 Da via 39000 Da to 100000 Da Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + serotonin Rattus norvegicus initial reaction in melatonin synthesis from serotonin CoA + N-acetylserotonin
-
 ?
acetyl-CoA + serotonin Ovis aries initial reaction in melatonin synthesis from serotonin CoA + N-acetylserotonin
-
 ?

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus
affinity chromatography on Sepharose CoA Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
pineal gland
-
 Rattus norvegicus
-
pineal gland
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000195
-
-
 Ovis aries

Storage Stability

Storage Stability Organism
0-2°C, up to 72 h Rattus norvegicus
0-2°C, up to 72 h Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + beta-phenylethylamine
-
 Rattus norvegicus CoA + N-(2-phenylethyl)-acetaminde
-
 ?
acetyl-CoA + beta-phenylethylamine
-
 Ovis aries CoA + N-(2-phenylethyl)-acetaminde
-
 ?
acetyl-CoA + serotonin i.e. 5-hydroxytryptamine Rattus norvegicus CoA + N-acetylserotonin
-
 ?
acetyl-CoA + serotonin i.e. 5-hydroxytryptamine Ovis aries CoA + N-acetylserotonin
-
 ?
acetyl-CoA + serotonin initial reaction in melatonin synthesis from serotonin Rattus norvegicus CoA + N-acetylserotonin
-
 ?
acetyl-CoA + serotonin initial reaction in melatonin synthesis from serotonin Ovis aries CoA + N-acetylserotonin
-
 ?
acetyl-CoA + tryptamine
-
 Rattus norvegicus CoA + N-acetyltryptamine
-
 ?
acetyl-CoA + tryptamine
-
 Ovis aries CoA + N-acetyltryptamine
-
 ?
additional information arylamines, such as aniline or p-phenetidine are very poor substrates Rattus norvegicus ?
-
 ?
additional information arylamines, such as aniline or p-phenetidine are very poor substrates Ovis aries ?
-
 ?