Literature summary for 2.3.1.86 extracted from

Dittrich, F.; Zajonc, D.; Huhne, K.; Hoja, U.; Ekici, A.; Greiner, E.; Klein, H.; Hofmann, J.; Bessoule, J.J.; Sperling, P.; Schweizer, E.
Fatty acid elongation in yeast. Biochemical characteristics of the enzyme system and isolation of elongation-defective mutants (1998), Eur. J. Biochem., 252, 477-485.

Search for more literature for 2.3.1.86

Activating Compound

Activating Compound	Comment	Organism	Structure
ATP	stimulatory at suboptimal but not at saturating substrate concentrations	Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment)	Organism
-	Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.05	-	lauroyl-CoA	-	Saccharomyces cerevisiae
0.13	-	palmitoyl-CoA	-	Saccharomyces cerevisiae
0.33	-	octanoyl-CoA	-	Saccharomyces cerevisiae
0.4	-	myristoyl-CoA	-	Saccharomyces cerevisiae
0.83	-	decanoyl-CoA	-	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	mutants lacking endogenous de novo fatty acid synthesis	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+	mutants require acyl-CoA primers of 10 or more carbon atoms, maximal activity with 12-14 carbon atoms	Saccharomyces cerevisiae	palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O	-	?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+	mutants require acyl-CoA primers of 10 or more carbon atoms, maximal activity with 12-14 carbon atoms	Saccharomyces cerevisiae X2180-1A	palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O	-	?
decanoyl-CoA + malonyl-CoA + NADPH + H+	-	Saccharomyces cerevisiae	?	-	?
decanoyl-CoA + malonyl-CoA + NADPH + H+	-	Saccharomyces cerevisiae X2180-1A	?	-	?
lauroyl-CoA + malonyl-CoA + NADPH + H+	-	Saccharomyces cerevisiae	?	-	?
lauroyl-CoA + malonyl-CoA + NADPH + H+	-	Saccharomyces cerevisiae X2180-1A	?	-	?
myristoyl-CoA + malonyl-CoA + NADPH + H+	-	Saccharomyces cerevisiae	?	-	?
myristoyl-CoA + malonyl-CoA + NADPH + H+	-	Saccharomyces cerevisiae X2180-1A	?	-	?
octanoyl-CoA + malonyl-CoA + NADPH + H+	-	Saccharomyces cerevisiae	?	-	?
octanoyl-CoA + malonyl-CoA + NADPH + H+	-	Saccharomyces cerevisiae X2180-1A	?	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)