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Literature summary for 2.3.1.85 extracted from

  • Liu, H.; Wu, X.; Dong, Z.; Luo, Z.; Zhao, Z.; Xu, Y.; Zhang, J.T.
    Fatty acid synthase causes drug resistance by inhibiting TNF-alpha and ceramide production (2013), J. Lipid Res., 54, 776-785.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine fatty acid synthase expression, which is upregulated in many human cancers, causes resistance to multiple anticancer drugs via inhibiting drug-induced ceramide production, caspase 8 activation, and apoptosis. Fatty acid synthase overexpression suppresses tumor necrosis factor-alpha production and nuclear factor-kappaB activation as well as drug-induced activation of neutral sphingomyelinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
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Homo sapiens
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