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Literature summary for 2.3.1.85 extracted from

  • Lau, D.S.; Archer, M.C.
    The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells (2010), Nutr. Cancer, 62, 116-121.
    View publication on PubMed
Search for more literature for 2.3.1.85

Inhibitors

Inhibitors Comment Organism Structure
(10E,12Z)-octadec-10,12-dienoic acid more potent inhibitor than (9Z,11E)-octadec-9,11-dienoic acid Homo sapiens
(9Z,11E)-octadec-9,11-dienoic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
colonic cancer cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-
SK-BR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Homo sapiens palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?

Synonyms

Synonyms Comment Organism
FAS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens (10E,12Z)-octadec-10,12-dienoic acid downregulates FAS expression in a concnetration-dependent manner, while (9Z,11E)-octadec-9,11-dienoic acid has no effect. (10E,12Z)-octadec-10,12-dienoic acid at 0.05 mM decreases FAS expression in MCF-7 cells by 52%, at 0.1 mM (10E,12Z)-octadec-10,12-dienoic acid, FAS protein is downregulated in MCF-7 (80%), LnCaP (27%), and HT-29 (61%) cells down