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Literature summary for 2.3.1.85 extracted from

  • Lu, S.; Archer, M.C.
    Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells (2010), Int. J. Cancer, 126, 416-425.
    View publication on PubMed
Search for more literature for 2.3.1.85

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
colonic cancer cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Homo sapiens palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?

Synonyms

Synonyms Comment Organism
FAS
-
 Homo sapiens
fatty acid synthase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens mithramycin inhibits FAS expression, transfection of transcription factor Sp1 siRNA suppresses FAS expression down
Homo sapiens transcription factor Sp3 and Sp4 siRNAs do not affect FAS expression additional information
Homo sapiens 17beta-estradiol increases FAS expression, estrogen induces FAS expression up