Literature summary for 2.3.1.85 extracted from

Schmidt, L.J.; Ballman, K.V.; Tindall, D.J.
Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride (2007), Prostate, 67, 1111-1120.

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Inhibitors

Inhibitors	Comment	Organism	Structure
dutasteride	at clinically relevant levels, inhibits FASN mRNA, protein expression and enzymatic activity in prostate cancer cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
LNCaP cell	at clinically relevant levels, inhibits FASN mRNA, protein expression and enzymatic activity in prostate cancer cells	Homo sapiens	-
PC-3 cell	at clinically relevant levels, inhibits FASN mRNA, protein expression and enzymatic activity in prostate cancer cells	Homo sapiens	-
VCaP cell	at clinically relevant levels, inhibits FASN mRNA, protein expression and enzymatic activity in prostate cancer cells	Homo sapiens	-

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Release 2023.1 (January 2023)