Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a potential therapeutic target to treat cancer and obesity. Acylphloroglucinol derivatives could be considered to be a promising class of FAS inhibitors | Gallus gallus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,1'-[methanediylbis(2,4,6-trihydroxy-5-methylbenzene-3,1-diyl)]dibutan-1-one | IC50: 0.0254 mM | Gallus gallus | |
1-(2,6-dihydroxy-4-methoxy-3-methylphenyl)butan-1-one | IC50: 0.0491 mM | Gallus gallus | |
2,2'-methanediylbis(3,5-dihydroxy-4,4-dimethyl-6-propanoylcyclohexa-2,5-dien-1-one) | IC50: 0.0602 mM | Gallus gallus | |
2-(3-butanoyl-2,4,6-trihydroxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethyl-6-propanoylcyclohexa-2,5-dien-1-one | IC50: 0.0231 mM | Gallus gallus | |
2-acetyl-6-(3-butanoyl-2,4,6-trihydroxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | IC50: 0.0287 mM | Gallus gallus | |
2-acetyl-6-(3-butanoyl-2,4,6-trihydroxybenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | IC50: 0.0297 mM | Gallus gallus | |
2-acetyl-6-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | IC50: 0.0717 mM | Gallus gallus | |
2-acetyl-6-{3-butanoyl-5-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-2,4,6-trihydroxybenzyl}-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | IC50: 0.031 mM | Gallus gallus | |
2-butanoyl-6-(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | IC50: 0.0326 mM | Gallus gallus | |
2-butanoyl-6-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | IC50: 0.0561 mM | Gallus gallus | |
cerulenin | IC50: 0.013 mM | Gallus gallus | |
luteolin | IC50: 0.0625 mM | Gallus gallus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Gallus gallus | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.013 | - |
IC50: 0.013 mM | Gallus gallus | 3-chloro-4-hydroxybenzoyl-[aryl-carrier protein] | |
0.0231 | - |
IC50: 0.0231 mM | Gallus gallus | 2-(3-butanoyl-2,4,6-trihydroxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethyl-6-propanoylcyclohexa-2,5-dien-1-one | |
0.0254 | - |
IC50: 0.0254 mM | Gallus gallus | 1,1'-[methanediylbis(2,4,6-trihydroxy-5-methylbenzene-3,1-diyl)]dibutan-1-one | |
0.0287 | - |
IC50: 0.0287 mM | Gallus gallus | 2-acetyl-6-(3-butanoyl-2,4,6-trihydroxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | |
0.0297 | - |
IC50: 0.0297 mM | Gallus gallus | 2-acetyl-6-(3-butanoyl-2,4,6-trihydroxybenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | |
0.031 | - |
IC50: 0.031 mM | Gallus gallus | 2-acetyl-6-{3-butanoyl-5-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-2,4,6-trihydroxybenzyl}-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | |
0.0326 | - |
IC50: 0.0326 mM | Gallus gallus | 2-butanoyl-6-(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | |
0.0491 | - |
IC50: 0.0491 mM | Gallus gallus | 1-(2,6-dihydroxy-4-methoxy-3-methylphenyl)butan-1-one | |
0.0561 | - |
IC50: 0.0561 mM | Gallus gallus | 2-butanoyl-6-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one | |
0.0602 | - |
IC50: 0.0602 mM | Gallus gallus | 2,2'-methanediylbis(3,5-dihydroxy-4,4-dimethyl-6-propanoylcyclohexa-2,5-dien-1-one) | |
0.0625 | - |
IC50: 0.0625 mM | Gallus gallus | 3-((1H-imidazo)-4-yl)-2-oxopropanoate | |
0.0717 | - |
IC50: 0.0717 mM | Gallus gallus | 2-acetyl-6-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one |