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Literature summary for 2.3.1.85 extracted from

  • Li, B.H.; Tian, W.X.
    Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance (2003), J. Enzyme Inhib. Med. Chem., 18, 349-356.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
galangin poor inhibition Gallus gallus
kaempferol 50% inhibition at 0.00298 mg/ml Gallus gallus
additional information inhibition by extract from rhizome of Alpinia officinarum, i.e. galangal. Inhibition consists of both reversible inhibition with an IC50-value of 0.0017 mg dried extract per ml, and biphasic slow-binding inactivation Gallus gallus
quercetin 50% inhibition at 0.0024 mg/ml, mixed type inhibition for substrate NADPH, competitive with substrate acetyl-CoA, noncompetitive with malonyl-CoA Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Gallus gallus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00183
-
 quercetin substrate NADPH, pH 7.0, 37°C Gallus gallus
0.00301
-
 quercetin substrate acetyl-CoA, pH 7.0, 37°C Gallus gallus