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Literature summary for 2.3.1.83 extracted from
- The esterification of dolichol by rat liver microsomes (1976), Biochemistry, 15, 1586-1591.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | 1%, several fold activation, inhibition at 3% | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibited by retinol | Rattus norvegicus | |
| Triton X-100 | high concentration, stimulation at low concentration | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.3 | - |
dolichol | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | predominant, subcellular distribution | Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no Mg2+ required | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
female, Sprague-Dawley strain | - |
| Rattus norvegicus Sprague-Dawley | - |
female, Sprague-Dawley strain | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| intestinal mucosa | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | predominant | Rattus norvegicus | - |
| pancreas | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-sn-phosphatidylcholine + dolichol | dolichols with 16-22 isopren units, no substrates are phosphatidylethanolamine, lysophosphatidylcholine, sphingomyelin and palmitoyl-CoA | Rattus norvegicus | 1-acyl-sn-glycero-3-phosphocholine + acyldolichol | - |
? | |
| 3-sn-phosphatidylcholine + dolichol | dolichols with 16-22 isopren units, no substrates are phosphatidylethanolamine, lysophosphatidylcholine, sphingomyelin and palmitoyl-CoA | Rattus norvegicus Sprague-Dawley | 1-acyl-sn-glycero-3-phosphocholine + acyldolichol | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 38 | - |
assay at | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
inactivation at room temperature and above | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.8 | 7.5 | approx. half-maximal activity at pH 4.8 and 7.5 | Rattus norvegicus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
and below, inactivation | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no requirement for CoA, ATP and Mg2+, separately or together | Rattus norvegicus |
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