BRENDA - Enzyme Database
show all sequences of 2.3.1.82

New plasmid-mediated aminoglycoside 6-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate

Jin, W.; Wachino, J.; Kimura, K.; Yamada, K.; Arakawa, Y.; J. Antimicrob. Chemother. 70, 1331-1337 (2015)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Serratia marcescens
A0A0B6VRK1
-
-
Serratia marcescens NUBL-11663
A0A0B6VRK1
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + amikacin
-
736322
Serratia marcescens
CoA + N6'-acetylamikacin
-
-
-
?
acetyl-CoA + amikacin
-
736322
Serratia marcescens NUBL-11663
CoA + N6'-acetylamikacin
-
-
-
?
acetyl-CoA + arbekacin
-
736322
Serratia marcescens
CoA + N6'-acetylarbekacin
-
-
-
?
acetyl-CoA + gentamicin
-
736322
Serratia marcescens
CoA + N6'-acetylgentamicin
-
-
-
?
acetyl-CoA + gentamicin
-
736322
Serratia marcescens NUBL-11663
CoA + N6'-acetylgentamicin
-
-
-
?
acetyl-CoA + isepamicin
-
736322
Serratia marcescens
CoA + 6'-N-acetylisepamicin
-
-
-
?
acetyl-CoA + kanamycin
-
736322
Serratia marcescens
CoA + N6'-acetylkanamycin
-
-
-
?
acetyl-CoA + kanamycin
-
736322
Serratia marcescens NUBL-11663
CoA + N6'-acetylkanamycin
-
-
-
?
acetyl-CoA + neomycin
-
736322
Serratia marcescens
CoA + N6'-acetylneomycin
-
-
-
?
acetyl-CoA + neomycin
-
736322
Serratia marcescens NUBL-11663
CoA + N6'-acetylneomycin
-
-
-
?
acetyl-CoA + netilmicin
-
736322
Serratia marcescens
CoA + 6'-N-acetylnetilmicin
-
-
-
?
acetyl-CoA + ribostamycin
-
736322
Serratia marcescens
CoA + 6'-N-acetylribostamycin
-
-
-
?
acetyl-CoA + sisomicin
-
736322
Serratia marcescens
CoA + 6'-N-acetylsisomicin
-
-
-
?
acetyl-CoA + tobramycin
-
736322
Serratia marcescens
CoA + 6'-N-acetyltobramycin
-
-
-
?
additional information
isoform AAC(6')-Ian acetylates 4,6- and 4,5-disubstituted 2-deoxystreptamine aminoglycosides
736322
Serratia marcescens
?
-
-
-
-
additional information
isoform AAC(6')-Ian acetylates 4,6- and 4,5-disubstituted 2-deoxystreptamine aminoglycosides
736322
Serratia marcescens NUBL-11663
?
-
-
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + amikacin
-
736322
Serratia marcescens
CoA + N6'-acetylamikacin
-
-
-
?
acetyl-CoA + amikacin
-
736322
Serratia marcescens NUBL-11663
CoA + N6'-acetylamikacin
-
-
-
?
acetyl-CoA + arbekacin
-
736322
Serratia marcescens
CoA + N6'-acetylarbekacin
-
-
-
?
acetyl-CoA + gentamicin
-
736322
Serratia marcescens
CoA + N6'-acetylgentamicin
-
-
-
?
acetyl-CoA + gentamicin
-
736322
Serratia marcescens NUBL-11663
CoA + N6'-acetylgentamicin
-
-
-
?
acetyl-CoA + isepamicin
-
736322
Serratia marcescens
CoA + 6'-N-acetylisepamicin
-
-
-
?
acetyl-CoA + kanamycin
-
736322
Serratia marcescens
CoA + N6'-acetylkanamycin
-
-
-
?
acetyl-CoA + kanamycin
-
736322
Serratia marcescens NUBL-11663
CoA + N6'-acetylkanamycin
-
-
-
?
acetyl-CoA + neomycin
-
736322
Serratia marcescens
CoA + N6'-acetylneomycin
-
-
-
?
acetyl-CoA + neomycin
-
736322
Serratia marcescens NUBL-11663
CoA + N6'-acetylneomycin
-
-
-
?
acetyl-CoA + netilmicin
-
736322
Serratia marcescens
CoA + 6'-N-acetylnetilmicin
-
-
-
?
acetyl-CoA + ribostamycin
-
736322
Serratia marcescens
CoA + 6'-N-acetylribostamycin
-
-
-
?
acetyl-CoA + sisomicin
-
736322
Serratia marcescens
CoA + 6'-N-acetylsisomicin
-
-
-
?
acetyl-CoA + tobramycin
-
736322
Serratia marcescens
CoA + 6'-N-acetyltobramycin
-
-
-
?
additional information
isoform AAC(6')-Ian acetylates 4,6- and 4,5-disubstituted 2-deoxystreptamine aminoglycosides
736322
Serratia marcescens
?
-
-
-
-
additional information
isoform AAC(6')-Ian acetylates 4,6- and 4,5-disubstituted 2-deoxystreptamine aminoglycosides
736322
Serratia marcescens NUBL-11663
?
-
-
-
-
Other publictions for EC 2.3.1.82
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735446
Li
Inhibition of aminoglycoside a ...
Pseudomonas aeruginosa, Staphylococcus aureus
Antimicrob. Agents Chemother.
59
4148-4156
2015
-
-
-
-
-
-
4
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
5
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735451
Chiem
Inhibition of aminoglycoside 6 ...
Klebsiella pneumoniae
Antimicrob. Agents Chemother.
59
5851-5853
2015
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
736322
Jin
New plasmid-mediated aminoglyc ...
Serratia marcescens, Serratia marcescens NUBL-11663
J. Antimicrob. Chemother.
70
1331-1337
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735363
Smith
Structure of the phosphotransf ...
Staphylococcus warneri
Acta Crystallogr. Sect. D
70
1561-1571
2014
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735444
Lin
Inhibition of aminoglycoside 6 ...
Acinetobacter baumannii 155, Acinetobacter baumannii
Antimicrob. Agents Chemother.
58
4238-4241
2014
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735445
Tada
Identification of a novel 6-N- ...
Stenotrophomonas maltophilia, Stenotrophomonas maltophilia IOMTU250
Antimicrob. Agents Chemother.
58
6324-6327
2014
-
-
-
-
-
-
-
9
-
-
-
-
-
2
-
-
-
-
-
-
-
-
15
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
15
-
-
-
-
9
-
-
-
-
-
1
1
-
9
9
735443
Tada
Novel 6'-N-aminoglycoside acet ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa NCGM1588
Antimicrob. Agents Chemother.
57
96-100
2013
-
-
-
-
-
-
-
-
2
-
-
-
-
6
-
-
-
-
-
-
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
15
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
735730
Green
Domain dissection and characte ...
Serratia marcescens
Biochimie
95
1319-1325
2013
-
-
1
-
1
-
-
18
-
-
-
-
-
1
-
-
-
-
-
-
-
-
8
-
-
-
-
18
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
18
-
-
-
-
-
-
-
-
18
18
735759
Lin
Inhibitors of the aminoglycosi ...
Escherichia coli
Bioorg. Med. Chem. Lett.
23
5694-5698
2013
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718594
Caldwell
Small-angle X-ray scattering a ...
Staphylococcus aureus
Antimicrob. Agents Chemother.
56
1899-1906
2012
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
719164
Kim
Identification of strain harbo ...
Escherichia coli, Klebsiella pneumoniae
BMB Rep.
44
262-266
2011
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
719603
Chowdhury
Transferable plasmid-mediated ...
Vibrio fluvialis
Int. J. Antimicrob. Agents
38
169-173
2011
-
1
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701732
Kitao
AAC(6)-Iaf, a novel aminoglyco ...
Pseudomonas aeruginosa
Antimicrob. Agents Chemother.
53
2327-2334
2009
-
-
1
-
-
-
-
-
-
-
1
-
-
5
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703215
Gao
Synthesis of a phosphonate-lin ...
Enterococcus faecium
Chemistry
15
2064-2070
2009
-
1
-
-
-
-
6
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
6
-
-
-
1
-
1
-
-
-
-
6
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706524
Zaunbrecher
Overexpression of the chromoso ...
Mycobacterium tuberculosis
Proc. Natl. Acad. Sci. USA
106
20004-20009
2009
-
1
1
-
-
-
-
2
-
-
-
1
-
2
-
-
1
-
-
-
-
-
3
-
1
-
-
-
1
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
2
-
-
-
1
-
-
-
1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
1
-
-
1
-
-
684411
Chu
Detection of broad-spectrum am ...
Enterococcus faecium
Anal. Biochem.
376
144-150
2008
-
-
-
-
-
-
-
6
-
-
-
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
685250
Magalhaes
Kinetic and structural analysi ...
Salmonella enterica
Biochemistry
47
579-584
2008
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702249
Vetting
Mechanistic and structural ana ...
Escherichia coli
Biochemistry
47
9825-9835
2008
-
-
1
1
-
-
2
8
-
-
-
-
-
2
-
-
1
-
-
-
-
-
4
-
-
-
-
8
1
-
-
1
-
-
-
-
-
1
1
1
-
-
-
2
-
8
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
702549
Gao
Synthesis and use of sulfonami ...
Enterococcus faecium
Bioorg. Med. Chem. Lett.
18
5518-5522
2008
-
-
-
-
-
-
5
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
5
-
-
-
-
-
1
-
-
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672253
Kim
Mechanistic characterization o ...
Pseudomonas aeruginosa
Biochemistry
46
5270-5282
2007
-
-
1
-
-
-
4
8
-
-
-
-
-
2
-
-
1
-
-
-
-
-
8
-
-
-
-
8
-
-
-
-
12
-
-
-
-
1
-
-
-
-
-
4
12
8
-
-
-
-
-
-
-
1
-
-
-
-
8
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
672563
Yan
The use of aminoglycoside deri ...
Enterococcus faecium
Bioorg. Med. Chem.
15
2944-2951
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672194
Kim
Characterization of the bifunc ...
Serratia marcescens
Biochemistry
45
8368-8377
2006
-
-
-
-
-
-
4
5
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
5
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
4
11
5
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
673770
Filipova
Occurrence of aminoglycoside-m ...
Enterococcus faecalis
Folia Microbiol. (Praha)
51
57-61
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675305
Gao
Synthesis and structure-activi ...
Enterococcus faecium
J. Med. Chem.
49
5273-5281
2006
-
-
-
-
-
-
15
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
15
-
-
-
-
-
-
-
-
-
-
15
15
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657563
Pourreza
Mutagenesis analysis of a cons ...
Escherichia coli
Antimicrob. Agents Chemother.
49
2979-2982
2005
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671064
Burk
Structures of aminoglycoside a ...
Enterococcus faecium
Acta Crystallogr. Sect. D
D61
1273-1279
2005
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671333
Gao
Regio- and chemoselective 6-N- ...
Enterococcus faecium
Angew. Chem. Int. Ed. Engl.
44
6859-6862
2005
-
-
-
-
-
-
6
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
6
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658066
Draker
Molecular mechanism of the ent ...
Enterococcus faecium
Biochemistry
43
446-454
2004
-
-
-
-
6
-
-
46
-
-
-
-
-
2
-
-
1
-
-
-
-
-
6
-
-
-
-
45
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
46
-
-
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
45
-
-
-
-
-
-
-
-
-
-
658426
Vetting
A bacterial acetyltransferase ...
Salmonella enterica
Chem. Biol.
11
565-573
2004
-
-
-
1
-
-
-
-
-
-
-
1
-
5
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659093
Hamano
Overexpression and characteriz ...
Streptomyces albulus, Streptomyces albulus IFO14147
J. Biochem.
136
517-524
2004
-
-
1
-
-
-
-
11
-
-
-
-
-
6
-
-
1
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
1
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657553
Magnet
Aminoglycoside resistance resu ...
Pseudomonas aeruginosa
Antimicrob. Agents Chemother.
47
1577-1583
2003
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657554
Dery
The aminoglycoside 6'-N-acetyl ...
Escherichia coli
Antimicrob. Agents Chemother.
47
2897-2902
2003
-
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657555
Casin
Salmonella enterica serovar ty ...
Salmonella enterica
Antimicrob. Agents Chemother.
47
697-703
2003
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658002
Draker
Kinetic mechanism of the GCN5- ...
Enterococcus faecium
Biochemistry
42
6565-6574
2003
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
5
1
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
5
1
-
-
-
10
-
-
-
-
-
-
-
-
-
-
658998
Li
Role of the acetyltransferase ...
Stenotrophomonas maltophilia
J. Antimicrob. Chemother.
51
803-811
2003
-
1
1
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659193
Boehr
The molecular basis of the exp ...
Enterococcus sp.
J. Biol. Chem.
278
12873-12880
2003
-
-
-
-
4
-
1
20
-
-
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
23
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
20
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
23
1
-
-
-
-
-
-
-
-
-
636912
Hegde
Thermodynamics of aminoglycosi ...
Salmonella enterica
Biochemistry
41
7519-7527
2002
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636913
Magnet
Kinetic and mutagenic characte ...
Salmonella enterica
Biochemistry
40
3700-3709
2001
-
-
1
-
1
-
3
24
-
-
4
1
-
2
-
-
-
-
-
-
-
-
14
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
3
-
24
-
-
4
1
-
-
-
-
-
-
-
-
14
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636914
Shmara
Systematic analysis of a conse ...
Klebsiella pneumoniae
Antimicrob. Agents Chemother.
45
3287-3292
2001
-
-
-
-
17
-
-
-
-
-
-
19
-
19
-
-
-
-
-
-
-
-
38
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
18
-
-
-
-
-
-
-
-
19
-
-
-
-
-
-
-
-
38
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636904
Wybenga-Groot
Crystal structure of an aminog ...
Enterococcus faecium
Structure
7
497-507
1999
-
-
-
1
-
-
1
1
-
-
-
1
-
4
-
-
-
-
-
-
-
-
5
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
636908
Zhu
Role of aminoglycoside 6'-acet ...
Actinomyces sp., Actinomyces sp. 8
J. Antibiot.
52
889-894
1999
-
-
1
-
-
-
-
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636909
Chavideh
Effects of F171 mutations in t ...
Klebsiella pneumoniae
Antimicrob. Agents Chemother.
43
2811-2812
1999
-
-
-
-
8
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636907
Casin
Aminoglycoside 6'-N-acetyltran ...
Citrobacter freundii, Enterobacter cloacae, Enterobacter cloacae EC 1562
Antimicrob. Agents Chemother.
42
209-215
1998
-
-
-
-
-
-
-
-
-
-
-
3
-
7
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636911
Panaite
Characterization of mutants of ...
Klebsiella pneumoniae
Plasmid
39
123-133
1998
-
-
1
-
2
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636910
Wright
Overexpression and characteriz ...
Enterococcus faecium
Antimicrob. Agents Chemother.
41
956-960
1997
-
-
1
-
1
-
7
14
1
-
-
1
-
3
-
-
1
-
-
-
-
-
14
-
-
-
-
14
-
-
-
-
6
-
-
-
-
1
-
-
1
-
-
7
6
14
1
-
-
1
-
-
-
1
-
-
-
-
14
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
636905
Culebras
pH Modulation of aminoglycosid ...
Staphylococcus epidermidis, Staphylococcus epidermidis RYC 13036
J. Antimicrob. Chemother.
37
881-889
1996
-
-
-
-
-
-
4
11
-
-
-
2
-
2
-
-
-
-
-
-
-
-
11
-
-
-
-
-
2
-
-
-
12
-
-
-
-
-
-
-
-
-
-
4
12
11
-
-
-
2
-
-
-
-
-
-
-
-
11
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
636918
Bunny K.L.; Hall R.M.; Stokes H.W.
New mobile gene cassettes cont ...
Klebsiella aerogenes
Antimicrob. Agents Chemother.
39
686-693
1995
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636906
Lambert
A spontaneous point mutation i ...
Pseudomonas fluorescens, Pseudomonas fluorescens BM2687
FEMS Microbiol. Lett.
115
297-304
1994
-
-
1
-
1
-
-
-
-
-
-
2
-
5
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636903
Rather
Genetic analysis of bacterial ...
Escherichia coli
J. Bacteriol.
174
3196-3203
1992
-
-
1
-
2
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636916
Tolmasky M.E.
Sequencing and expression of a ...
Klebsiella pneumoniae
Plasmid
24
218-226
1990
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636915
Nobuta K.; Tolmasky M.E.; Crosa L.M.; Crosa J.H.
Sequencing and expression of t ...
Klebsiella pneumoniae
J. Bacteriol.
170
3769-3773
1988
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636917
Tenover F.C.; Filpula D.; Phillips K.L.; Plorde J.J.
Cloning and sequencing of a ge ...
Citrobacter koseri
J. Bacteriol.
170
471-473
1988
-
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636919
Van Nhieu G.T.; Collatz E.
Primary structure of an aminog ...
Serratia marcescens
J. Bacteriol.
169
5708-5714
1987
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636901
Meyer
Characterization of aminoglyco ...
Escherichia coli, Escherichia coli NR79, Pseudomonas aeruginosa, Serratia marcescens, Serratia marcescens VU12944/77, Streptomyces kanamyceticus
J. Antimicrob. Chemother.
15
271-282
1985
-
-
2
-
-
-
-
4
-
-
4
6
-
9
-
-
4
-
-
-
-
-
33
3
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
4
-
-
4
6
-
-
-
4
-
-
-
-
33
3
-
-
-
-
5
-
-
-
-
-
-
-
-
-
636902
Martel
Kinetic studies of aminoglycos ...
Staphylococcus aureus
Eur. J. Biochem.
133
515-521
1983
-
-
-
-
-
1
6
-
-
-
1
1
-
1
-
-
1
1
-
-
1
-
6
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
6
4
-
-
-
1
1
-
-
-
1
-
-
1
-
6
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
636899
Le Goffic
Resistance to aminosides induc ...
Escherichia coli, Escherichia coli CS2R2, Moraxella sp.
Biochimie
56
893-897
1974
-
-
-
-
-
-
1
5
-
-
-
3
-
3
-
-
1
-
-
-
-
1
24
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
-
-
3
-
-
-
1
-
-
-
1
24
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
487272
Benveniste
Aminoglycoside antibiotic-inac ...
Streptomyces kanamyceticus
Proc. Natl. Acad. Sci. USA
70
2276-2280
1973
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
636898
Benveniste
Enzymatic acetylation of amino ...
Escherichia coli
Biochemistry
10
1787-1796
1971
-
-
-
-
-
2
6
-
-
1
-
2
-
1
-
-
1
-
-
-
-
1
18
-
-
-
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
2
-
6
-
-
-
1
-
2
-
-
-
1
-
-
-
1
18
-
-
-
2
-
2
1
-
-
-
-
-
-
-
-