Literature summary for 2.3.1.82 extracted from

Chiem, K.; Fuentes, B.A.; Lin, D.L.; Tran, T.; Jackson, A.; Ramirez, M.S.; Tolmasky, M.E.
Inhibition of aminoglycoside 6-N-acetyltransferase type Ib-mediated amikacin resistance in Klebsiella pneumoniae by zinc and copper pyrithione (2015), Antimicrob. Agents Chemother., 59, 5851-5853.

Search for more literature for 2.3.1.82

Inhibitors

Inhibitors	Comment	Organism	Structure
Cu2+	the growth of an amikacin-resistant Klebsiella pneumoniae strain is inhibited when amikacin is supplemented by the addition of Zn2+ or Cu2+ in complex with the ionophore pyrithione	Klebsiella pneumoniae
Zn2+	the growth of an amikacin-resistant Klebsiella pneumoniae strain is inhibited when amikacin is supplemented by the addition of Zn2+ or Cu2+ in complex with the ionophore pyrithione. Addition of 5 microM Zn-pyrithione to cultures containing 16 microg/ml amikacin results in full growth inhibition	Klebsiella pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	Q7B8A1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + amikacin	-	Klebsiella pneumoniae	CoA + 6'-N-acetylamikacin	-	?

Synonyms

Synonyms	Comment	Organism
AAC(6')-Ib	-	Klebsiella pneumoniae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0028	-	pH not specified in the publication, temperature not specified in the publication	Klebsiella pneumoniae	Cu2+

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)