Cloned (Comment) | Organism |
---|---|
aac(6')-Ib‘ gene | Pseudomonas fluorescens |
Protein Variants | Comment | Organism |
---|---|---|
S83L | the aac(6')-Ib‘ gene from strain BM2687 and the aac(6')-Ib gene from strain BM2656 show total identity with the exception of a C to T transition that results in a Ser to Leu substitution at position 83 of the deduced polypeptide. The enzyme encoded by aac(6')-Ib‘ shows resistance to gentamicin but not to amikacin. The enzyme encoded by aac(6')-Ib shows resistance to amikacin but not to gentamicin | Pseudomonas fluorescens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Pseudomonas fluorescens | involved in resistance to antibiotics | ? | - |
? | |
additional information | Pseudomonas fluorescens BM2687 | involved in resistance to antibiotics | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas fluorescens | - |
gene aac(6')-Ib' | - |
Pseudomonas fluorescens BM2687 | - |
gene aac(6')-Ib' | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 2'-N-ethylnetilmicin | - |
Pseudomonas fluorescens | CoA + N6'-acetyl-2'-N-ethylnetilmicin | - |
? | |
acetyl-CoA + amikacin | gentamicin complex: C1 41%, C1a 26% and C2 33%. The aac(6')-Ib‘ gene from strain BM2687 and the aac(6')-Ib gene from strain BM2656 show total identity with the exception of a C to T transition that results in a Ser to Leu substitution at position 83 of the deduced polypeptide. The enzyme encoded by aac(6')-Ib‘ shows resistance to gentamicin but not to amikacin. The enzyme encoded by aac(6')-Ib shows resistance to amikacin but not to gentamicin | Pseudomonas fluorescens | CoA + N6'-acetylamikacin | - |
? | |
acetyl-CoA + amikacin | gentamicin complex: C1 41%, C1a 26% and C2 33%. The aac(6')-Ib‘ gene from strain BM2687 and the aac(6')-Ib gene from strain BM2656 show total identity with the exception of a C to T transition that results in a Ser to Leu substitution at position 83 of the deduced polypeptide. The enzyme encoded by aac(6')-Ib‘ shows resistance to gentamicin but not to amikacin. The enzyme encoded by aac(6')-Ib shows resistance to amikacin but not to gentamicin | Pseudomonas fluorescens BM2687 | CoA + N6'-acetylamikacin | - |
? | |
acetyl-CoA + gentamicin C1a | gentamicin complex: C1 41%, C1a 26% and C2 33%. The aac(6')-Ib‘ gene from strain BM2687 and the aac(6')-Ib gene from strain BM2656 show total identity with the exception of a C to T transition that results in a Ser to Leu substitution at position 83 of the deduced polypeptide. The enzyme encoded by aac(6')-Ib‘ shows resistance to gentamicin but not to amikacin. The enzyme encoded by aac(6')-Ib shows resistance to amikacin but not to gentamicin | Pseudomonas fluorescens | CoA + N6'-acetylgentamicin C1a | - |
? | |
acetyl-CoA + gentamicin C1a | gentamicin complex: C1 41%, C1a 26% and C2 33%. The aac(6')-Ib‘ gene from strain BM2687 and the aac(6')-Ib gene from strain BM2656 show total identity with the exception of a C to T transition that results in a Ser to Leu substitution at position 83 of the deduced polypeptide. The enzyme encoded by aac(6')-Ib‘ shows resistance to gentamicin but not to amikacin. The enzyme encoded by aac(6')-Ib shows resistance to amikacin but not to gentamicin | Pseudomonas fluorescens BM2687 | CoA + N6'-acetylgentamicin C1a | - |
? | |
acetyl-CoA + netilmicin | - |
Pseudomonas fluorescens | CoA + N6'-acetylnetilmicin | - |
? | |
acetyl-CoA + netilmicin | - |
Pseudomonas fluorescens BM2687 | CoA + N6'-acetylnetilmicin | - |
? | |
acetyl-CoA + tobramycin | - |
Pseudomonas fluorescens | CoA + N6'-acetyltobramycin | - |
? | |
acetyl-CoA + tobramycin | - |
Pseudomonas fluorescens BM2687 | CoA + N6'-acetyltobramycin | - |
? | |
additional information | involved in resistance to antibiotics | Pseudomonas fluorescens | ? | - |
? | |
additional information | involved in resistance to antibiotics | Pseudomonas fluorescens BM2687 | ? | - |
? |