Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion technique, crystal structure of the 6'-N-acetyltransferase type li in complex with acetyl-CoA determined at 2.7 A resolution | Enterococcus faecium |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
poly-L-Lys | substrate inhibition | Enterococcus faecium |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.038 | - |
poly-L-Lys | pH 7.5, 37°C | Enterococcus faecium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Enterococcus faecium | involved in resistance to antibiotics | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterococcus faecium | Q47764 | 6'-N-acetyltransferase type li, transformation of Escherichia coli methionine auxotroph B834(DE3)/pLys S with a pPLaac-1 overexpression plasmid containing the aac(6')-li gene | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone | a mixture of calf histones enriched in H3 and H4 | Enterococcus faecium | CoA + ? | - |
? | |
acetyl-CoA + myelin basic protein | - |
Enterococcus faecium | CoA + ? | - |
? | |
acetyl-CoA + poly-L-Lys | - |
Enterococcus faecium | CoA + ? | - |
? | |
additional information | no activity with aminoglycoside kinase APH(3')-IIIa, yeast homoserine dehydrogenase, spermine and serotonin | Enterococcus faecium | ? | - |
? | |
additional information | involved in resistance to antibiotics | Enterococcus faecium | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0019 | - |
poly-L-Lys | pH 7.5, 37°C | Enterococcus faecium |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.78 | - |
poly-L-Lys | pH 7.5, 37°C | Enterococcus faecium |