BRENDA - Enzyme Database
show all sequences of 2.3.1.81

AAC(3)-XI, a new aminoglycoside 3-N-acetyltransferase from Corynebacterium striatum

Galimand, M.; Fishovitz, J.; Lambert, T.; Barbe, V.; Zajicek, J.; Mobashery, S.; Courvalin, P.; Antimicrob. Agents Chemother. 59, 5647-5653 (2015)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
gne aac(3)-XI, DNA and amino acid sequence determination and analysis, genomic organization, the aac(3)-XI gene is located downstream from a gene for a transposase (TnpCx) and upstream from that for a two-component system sensor kinase, the sequence upstream from aac(3)-XI does not reveal any putative promoter, recombinant expression of His-tagged enzyme in Escherichia coli strains TOP10 and BL21 Star(DE3)
Corynebacterium striatum
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
strain BM4687 is resistant to gentamicin and tobramycin but susceptible to kanamycin A and amikacin
Corynebacterium striatum
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Michaelis-Menten kinetics
Corynebacterium striatum
0.0027
-
acetyl-CoA
pH 6.0, 37°C; recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
0.0092
-
dibekacin
pH 6.0, 37°C; recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
0.0138
-
kanamycin B
pH 6.0, 37°C; recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
acetyl-CoA + a 2-deoxystreptamine antibiotic
Corynebacterium striatum
-
CoA + N3-acetyl-2-deoxystreptamine antibiotic
-
-
?
acetyl-CoA + a 2-deoxystreptamine antibiotic
Corynebacterium striatum BM4687
-
CoA + N3-acetyl-2-deoxystreptamine antibiotic
-
-
?
acetyl-CoA + dibekacin
Corynebacterium striatum
-
CoA + N3-acetyldibekacin
-
-
?
acetyl-CoA + dibekacin
Corynebacterium striatum BM4687
-
CoA + N3-acetyldibekacin
-
-
?
acetyl-CoA + kanamycin B
Corynebacterium striatum
-
CoA + N3-acetylkanamycin B
-
-
?
acetyl-CoA + kanamycin B
Corynebacterium striatum BM4687
-
CoA + N3-acetylkanamycin B
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Corynebacterium striatum
A0A0K2X0F2
gene aac(3)-XI
-
Corynebacterium striatum
-
strain isolated from the heel biopsy specimen of an 80-year-old diabetic woman
-
Corynebacterium striatum BM4687
A0A0K2X0F2
gene aac(3)-XI
-
Corynebacterium striatum BM4687
-
strain isolated from the heel biopsy specimen of an 80-year-old diabetic woman
-
Purification (Commentary)
Purification (Commentary)
Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21 Star(DE3) by nickel affinity chromatography and ultrafiltration
Corynebacterium striatum
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
acetyl-CoA + a 2-deoxystreptamine antibiotic
-
735448
Corynebacterium striatum
CoA + N3-acetyl-2-deoxystreptamine antibiotic
-
-
-
?
acetyl-CoA + a 2-deoxystreptamine antibiotic
-
735448
Corynebacterium striatum BM4687
CoA + N3-acetyl-2-deoxystreptamine antibiotic
-
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum
CoA + N3''-acetyldibekacin
-
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum BM4687
CoA + N3''-acetyldibekacin
-
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum
CoA + N3-acetyldibekacin
-
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum
CoA + N3-acetyldibekacin
product identification by high-field NMR
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum BM4687
CoA + N3-acetyldibekacin
-
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum BM4687
CoA + N3-acetyldibekacin
product identification by high-field NMR
-
-
?
acetyl-CoA + fortimicin
-
735448
Corynebacterium striatum
CoA + N3-acetylfortimicin
-
-
-
?
acetyl-CoA + gentamicin C1A
-
735448
Corynebacterium striatum
CoA + N3-acetylgentamicin C1A
-
-
-
?
acetyl-CoA + kanamycin B
-
735448
Corynebacterium striatum
CoA + N3'-acetylkanamycin B
-
-
-
-
acetyl-CoA + kanamycin B
-
735448
Corynebacterium striatum BM4687
CoA + N3'-acetylkanamycin B
-
-
-
-
acetyl-CoA + kanamycin B
-
735448
Corynebacterium striatum
CoA + N3-acetylkanamycin B
-
-
-
?
acetyl-CoA + kanamycin B
-
735448
Corynebacterium striatum BM4687
CoA + N3-acetylkanamycin B
-
-
-
?
acetyl-CoA + sisomicin
-
735448
Corynebacterium striatum
CoA + N3-acetylsisomicin
-
-
-
?
acetyl-CoA + tobramycin
-
735448
Corynebacterium striatum
CoA + N3-acetyltobramycin
-
-
-
?
additional information
the enzyme shows a unique profile of the reaction. No activity with kanamycin A, amikacin, netilmicin, neomycin B, and apramycin
735448
Corynebacterium striatum
?
-
-
-
-
additional information
the enzyme shows a unique profile of the reaction. No activity with kanamycin A, amikacin, netilmicin, neomycin B, and apramycin
735448
Corynebacterium striatum BM4687
?
-
-
-
-
Synonyms
Synonyms
Commentary
Organism
AAC(3)-XI
-
Corynebacterium striatum
aminoglycoside 3-N-acetyltransferase type XI
-
Corynebacterium striatum
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Corynebacterium striatum
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.17
-
dibekacin
pH 6.0, 37°C; recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
0.23
-
kanamycin B
pH 6.0, 37°C; recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
0.24
-
acetyl-CoA
pH 6.0, 37°C; recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6
-
assay at
Corynebacterium striatum
Cofactor
Cofactor
Commentary
Organism
Structure
acetyl-CoA
-
Corynebacterium striatum
Cloned(Commentary) (protein specific)
Commentary
Organism
gne aac(3)-XI, DNA and amino acid sequence determination and analysis, genomic organization, the aac(3)-XI gene is located downstream from a gene for a transposase (TnpCx) and upstream from that for a two-component system sensor kinase, the sequence upstream from aac(3)-XI does not reveal any putative promoter, recombinant expression of His-tagged enzyme in Escherichia coli strains TOP10 and BL21 Star(DE3)
Corynebacterium striatum
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
acetyl-CoA
-
Corynebacterium striatum
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
strain BM4687 is resistant to gentamicin and tobramycin but susceptible to kanamycin A and amikacin
Corynebacterium striatum
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Michaelis-Menten kinetics
Corynebacterium striatum
0.0027
-
acetyl-CoA
pH 6.0, 37°C
Corynebacterium striatum
0.0027
-
acetyl-CoA
recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
0.0092
-
dibekacin
pH 6.0, 37°C
Corynebacterium striatum
0.0092
-
dibekacin
recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
0.0138
-
kanamycin B
pH 6.0, 37°C
Corynebacterium striatum
0.0138
-
kanamycin B
recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
acetyl-CoA + a 2-deoxystreptamine antibiotic
Corynebacterium striatum
-
CoA + N3-acetyl-2-deoxystreptamine antibiotic
-
-
?
acetyl-CoA + a 2-deoxystreptamine antibiotic
Corynebacterium striatum BM4687
-
CoA + N3-acetyl-2-deoxystreptamine antibiotic
-
-
?
acetyl-CoA + dibekacin
Corynebacterium striatum
-
CoA + N3-acetyldibekacin
-
-
?
acetyl-CoA + dibekacin
Corynebacterium striatum BM4687
-
CoA + N3-acetyldibekacin
-
-
?
acetyl-CoA + kanamycin B
Corynebacterium striatum
-
CoA + N3-acetylkanamycin B
-
-
?
acetyl-CoA + kanamycin B
Corynebacterium striatum BM4687
-
CoA + N3-acetylkanamycin B
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21 Star(DE3) by nickel affinity chromatography and ultrafiltration
Corynebacterium striatum
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
acetyl-CoA + a 2-deoxystreptamine antibiotic
-
735448
Corynebacterium striatum
CoA + N3-acetyl-2-deoxystreptamine antibiotic
-
-
-
?
acetyl-CoA + a 2-deoxystreptamine antibiotic
-
735448
Corynebacterium striatum BM4687
CoA + N3-acetyl-2-deoxystreptamine antibiotic
-
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum
CoA + N3''-acetyldibekacin
-
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum BM4687
CoA + N3''-acetyldibekacin
-
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum
CoA + N3-acetyldibekacin
-
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum
CoA + N3-acetyldibekacin
product identification by high-field NMR
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum BM4687
CoA + N3-acetyldibekacin
-
-
-
?
acetyl-CoA + dibekacin
-
735448
Corynebacterium striatum BM4687
CoA + N3-acetyldibekacin
product identification by high-field NMR
-
-
?
acetyl-CoA + fortimicin
-
735448
Corynebacterium striatum
CoA + N3-acetylfortimicin
-
-
-
?
acetyl-CoA + gentamicin C1A
-
735448
Corynebacterium striatum
CoA + N3-acetylgentamicin C1A
-
-
-
?
acetyl-CoA + kanamycin B
-
735448
Corynebacterium striatum
CoA + N3'-acetylkanamycin B
-
-
-
-
acetyl-CoA + kanamycin B
-
735448
Corynebacterium striatum BM4687
CoA + N3'-acetylkanamycin B
-
-
-
-
acetyl-CoA + kanamycin B
-
735448
Corynebacterium striatum
CoA + N3-acetylkanamycin B
-
-
-
?
acetyl-CoA + kanamycin B
-
735448
Corynebacterium striatum BM4687
CoA + N3-acetylkanamycin B
-
-
-
?
acetyl-CoA + sisomicin
-
735448
Corynebacterium striatum
CoA + N3-acetylsisomicin
-
-
-
?
acetyl-CoA + tobramycin
-
735448
Corynebacterium striatum
CoA + N3-acetyltobramycin
-
-
-
?
additional information
the enzyme shows a unique profile of the reaction. No activity with kanamycin A, amikacin, netilmicin, neomycin B, and apramycin
735448
Corynebacterium striatum
?
-
-
-
-
additional information
the enzyme shows a unique profile of the reaction. No activity with kanamycin A, amikacin, netilmicin, neomycin B, and apramycin
735448
Corynebacterium striatum BM4687
?
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Corynebacterium striatum
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.17
-
dibekacin
pH 6.0, 37°C
Corynebacterium striatum
0.17
-
dibekacin
recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
0.23
-
kanamycin B
pH 6.0, 37°C
Corynebacterium striatum
0.23
-
kanamycin B
recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
0.24
-
acetyl-CoA
pH 6.0, 37°C
Corynebacterium striatum
0.24
-
acetyl-CoA
recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6
-
assay at
Corynebacterium striatum
General Information
General Information
Commentary
Organism
evolution
aminoglycoside 3-N-acetyltransferases [AAC(3)] are widely distributed in Gram-negative bacteria and are categorized in five types (I, II, III, IV, and VI). To date, only four are identified in the Gram-positive aminoglycoside producers, overview
Corynebacterium striatum
physiological function
expression in Escherichia coli confers resistance to gentamicin, tobramycin, sisomicin, dibekacin, and fortimicin, the MICs of kanamycin A, netilmicin, amikacin, apramycin, and neomycin B remaining unchanged
Corynebacterium striatum
General Information (protein specific)
General Information
Commentary
Organism
evolution
aminoglycoside 3-N-acetyltransferases [AAC(3)] are widely distributed in Gram-negative bacteria and are categorized in five types (I, II, III, IV, and VI). To date, only four are identified in the Gram-positive aminoglycoside producers, overview
Corynebacterium striatum
physiological function
expression in Escherichia coli confers resistance to gentamicin, tobramycin, sisomicin, dibekacin, and fortimicin, the MICs of kanamycin A, netilmicin, amikacin, apramycin, and neomycin B remaining unchanged
Corynebacterium striatum
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
17
-
kanamycin B
pH 6.0, 37°C; recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
18
-
dibekacin
pH 6.0, 37°C; recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
89
-
acetyl-CoA
pH 6.0, 37°C; recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
17
-
kanamycin B
pH 6.0, 37°C
Corynebacterium striatum
17
-
kanamycin B
recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
18
-
dibekacin
pH 6.0, 37°C
Corynebacterium striatum
18
-
dibekacin
recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
89
-
acetyl-CoA
pH 6.0, 37°C
Corynebacterium striatum
89
-
acetyl-CoA
recombinant His-tagged enzyme, pH 6.0, 37°C
Corynebacterium striatum
Other publictions for EC 2.3.1.81
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735448
Galimand
AAC(3)-XI, a new aminoglycosid ...
Corynebacterium striatum, Corynebacterium striatum BM4687
Antimicrob. Agents Chemother.
59
5647-5653
2015
-
-
1
-
-
-
1
4
-
-
-
6
-
10
-
-
1
-
-
1
-
-
18
-
3
1
-
-
3
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
7
-
-
-
6
-
-
-
1
-
1
-
-
18
-
1
-
-
6
1
-
-
-
-
2
2
-
3
6
736260
Atasoy
Modifying enzymes related amin ...
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Int. J. Clin. Exp. Med.
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2874-2880
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-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
735678
Norris
Protein dynamics are influence ...
Pseudomonas aeruginosa
Biochemistry
53
30-38
2014
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
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8
-
1
-
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-
7
-
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-
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4
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-
-
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-
8
-
-
-
-
7
-
-
-
-
-
-
-
-
4
4
703205
Green
Exploring the substrate promis ...
Escherichia coli
ChemBioChem
11
119-126
2010
-
1
1
-
-
-
-
20
-
-
-
-
-
1
-
-
-
-
-
-
-
-
34
-
4
-
-
-
20
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
20
-
-
-
-
-
-
-
-
-
-
-
-
34
-
-
-
-
20
1
-
-
-
-
-
-
-
-
-
718870
Norris
Thermodynamics and kinetics of ...
Pseudomonas aeruginosa
Biochemistry
49
4027-4035
2010
-
-
1
-
-
-
5
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
9
-
1
-
-
-
8
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
5
2
8
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
8
-
-
-
-
-
-
-
-
8
8
718871
Norris
Interactions of coenzyme A wit ...
Pseudomonas aeruginosa
Biochemistry
49
4036-4042
2010
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
4
-
-
-
-
-
-
-
-
4
4
703467
Cabrera
Characterization of the enzyme ...
Salmonella enterica
Enferm. Infecc. Microbiol. Clin.
27
453-456
2009
-
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
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1
-
2
-
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-
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-
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-
1
-
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-
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1
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-
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1
-
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671371
Elbourne
Gene cassette encoding a 3-N-a ...
Saccharophagus degradans
Antimicrob. Agents Chemother.
50
2270-2271
2006
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657558
Levings
New integron-associated gene c ...
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49
1238-1241
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-
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3
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672007
Magalhaes
The kinetic mechanism of AAC3- ...
Escherichia coli, Escherichia coli BL21(DE3) pLysS
Biochemistry
44
16275-16283
2005
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-
1
-
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-
3
15
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4
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-
3
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1
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20
1
3
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15
1
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1
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1
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3
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15
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4
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1
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20
1
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15
1
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-
1
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672534
Welch
Discovery of non-carbohydrate ...
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Bioorg. Med. Chem.
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6252-6263
2005
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1
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3
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675934
Subba
The ribostamycin biosynthetic ...
Streptomyces ribosidificus
Mol. Cell
20
90-96
2005
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-
1
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1
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3
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1
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487553
Riccio
Novel 3-N-aminoglycoside acety ...
Pseudomonas aeruginosa
Antimicrob. Agents Chemother.
47
1746-1748
2003
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1
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1
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3
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10
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10
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487552
Tsuchizaki
-
Rapid characterization by colo ...
Streptomyces griseus
Actinomycetologica
15
23-29
2001
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-
-
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1
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1
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487551
Ishikawa
Identification and characteriz ...
Streptomyces griseus
Antimicrob. Agents Chemother.
44
437-440
2000
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1
1
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2
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1
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1
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487550
Wolf
Crystal structure of a GCN5-re ...
Serratia marcescens
Cell
94
439-449
1998
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1
1
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1
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1
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3
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1
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1
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1
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1
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1
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1
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1
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Gomez-Lus
Stability of dactimicin to ami ...
Escherichia coli
Drugs Exp. Clin. Res.
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129-132
1989
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2
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637304
Bongaerts
Effect of aminoglycoside conce ...
Escherichia coli, Escherichia coli JR88
Antimicrob. Agents Chemother.
32
740-746
1988
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1
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10
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1
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10
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637300
Angelatou
Purification and properties of ...
Pseudomonas aeruginosa
J. Antibiot.
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1982
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3
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1
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1
2
11
-
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1
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1
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1
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1
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2
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3
-
1
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3
1
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1
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1
2
11
-
1
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1
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1
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661049
Coombe
Purification and properties of ...
Pseudomonas aeruginosa
Biochemistry
21
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1982
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1
2
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1
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2
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1
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2
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2
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1
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487549
Davies
Enzymatic modification of amin ...
Arizona sp., Escherichia coli, Klebsiella pneumoniae
Antimicrob. Agents Chemother.
14
69-72
1978
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3
2
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3
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3
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2
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3
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Williams
Kinetic mechanisms of gentamic ...
Escherichia coli, Escherichia coli C600
J. Biol. Chem.
253
5902-5907
1978
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6
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1
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9
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5
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6
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1
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637299
Biddlecome
Enzymatic modification of amin ...
Escherichia coli, Escherichia coli R135/C600, Pseudomonas aeruginosa, Pseudomonas aeruginosa Travers PST
Antimicrob. Agents Chemother.
9
951-955
1976
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2
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22
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2
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