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Literature summary for 2.3.1.78 extracted from

  • Bame, K.J.; Rome, L.H.
    Acetyl-CoA: alpha-glucosaminide N-acetyltransferase from rat liver (1987), Methods Enzymol., 138, 607-611.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
methyl methanethiolsulfonate activates the membrane-bound enzyme 1.5fold Rattus norvegicus
taurodeoxycholate 2 to 3fold increase of activity Rattus norvegicus
Triton X-100 2 to 3fold increase of activity Rattus norvegicus

General Stability

General Stability Organism
solubilized enzyme, not stable Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol membrane-bound enzyme is insensitive, solubilized enzyme is inactivated Rattus norvegicus
alpha-D-glucosamine 6-phosphate weak Rattus norvegicus
alpha-methyl-D-glucose weak Rattus norvegicus
cellobiose weak Rattus norvegicus
chitin
-
Rattus norvegicus
chitosan
-
Rattus norvegicus
coenzyme A noncompetitive Rattus norvegicus
dithiothreitol solubilized protein Rattus norvegicus
maltose weak Rattus norvegicus
additional information iodoacetamide and N-ethylmaleimide are not inhibitory Rattus norvegicus
N-acetyl-alpha-D-glucosamine
-
Rattus norvegicus
N-acetyl-beta-D-glucosamine noncompetitive against acetyl-CoA Rattus norvegicus
N-laurylsarcosine 1% Rattus norvegicus
p-chloromercuribenzoate
-
Rattus norvegicus
sucrose weak Rattus norvegicus
Zwittergent 1% Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.29 0.3 alpha-D-glucosamine
-
Rattus norvegicus
0.55
-
acetyl-CoA
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + heparan sulfate alpha-D-glucosaminide Rattus norvegicus
-
CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide di-iso ping-pong mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-70°C, membrane-bound enzyme, 12 months stable Rattus norvegicus
4°C, solubilized enzyme, 25% loss of activity after 7 days Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + alpha-D-glucosamine
-
Rattus norvegicus CoA + N-acetyl-alpha-D-glucosamine
-
?
acetyl-CoA + heparan sulfate alpha-D-glucosaminide
-
Rattus norvegicus CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?
acetyl-CoA + heparan sulfate alpha-D-glucosaminide brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed Rattus norvegicus CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45
-
membrane-bound form Rattus norvegicus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
45 55
-
Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
5 min, solubilized enzyme, 50% loss of activity Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
above, broad maximum Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3 7 coenzyme A
-
Rattus norvegicus
15 17 N-acetyl-alpha-D-glucosamine
-
Rattus norvegicus