Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + heparan sulfate alpha-D-glucosaminide | Homo sapiens | initial step in heparan sulfate degradation | CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? | |
additional information | Homo sapiens | enzyme deficiency leads to Sanfilippo syndrome type C, i.e. mucopolysaccharidosis III C | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin fibroblast | deficiency on fibroblasts from patients with Sanfillippo syndrome type C | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + heparan sulfate alpha-D-glucosaminide | brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed | Homo sapiens | CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? | |
acetyl-CoA + heparan sulfate alpha-D-glucosaminide | initial step in heparan sulfate degradation | Homo sapiens | CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? | |
additional information | enzyme deficiency leads to Sanfilippo syndrome type C, i.e. mucopolysaccharidosis III C | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
about | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 7 | half-maximal activity at pH 5.0 and pH 7.0 | Homo sapiens |