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Literature summary for 2.3.1.76 extracted from

  • Yen, C.L.; Brown Iv, C.H.; Monetti, M.; Farese, R.V., Jr.
    A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters (2005), J. Lipid Res., 46, 2388-2397.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
chromosomal location, expression of the FLAG-tagged enzyme in Spodoptera frugiperda Sf9 cells and in COS-7 cells Homo sapiens
expression in insect cells or in COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the multifunctional O-acyltransferase likely plays an important role in lipid metabolism in human skin ?
-
?
additional information Homo sapiens the multifunctional enzyme plays an important role in lipid metabolism in human skin ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Homo sapiens
-
liver very low expression level Homo sapiens
-
lung
-
Homo sapiens
-
pancreas very low expression level Homo sapiens
-
skin highly expressed in Homo sapiens
-
skin high expression level Homo sapiens
-
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans retinol + palmitoyl-CoA
-
Homo sapiens all-trans-retinyl palmitate + CoA
-
?
additional information the multifunctional O-acyltransferase likely plays an important role in lipid metabolism in human skin Homo sapiens ?
-
?
additional information the multifunctional enzyme plays an important role in lipid metabolism in human skin Homo sapiens ?
-
?
additional information the multifunctional O-acetyltransferase is catalyzing the reactions of the acyl-CoA:retinol acyltransferase, of the monoacylglycerol transferase, EC 2.3.1.22, of the diacylglycerol transferase, EC 2.3.1.20, and of the wax synthase, EC 2.3.1.75, overview Homo sapiens ?
-
?
palmitoyl-CoA + retinol
-
Homo sapiens CoA + retinylpalmitate
-
?

Synonyms

Synonyms Comment Organism
acyl-CoA:retinol acyltransferase
-
Homo sapiens
ArAT
-
Homo sapiens
MFAT
-
Homo sapiens
More the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase 2/acyl-CoA:monoacylglycerol acyltransferase, MGAT, gene family Homo sapiens
multifunctional O-acyltransferase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens