BRENDA - Enzyme Database show
show all sequences of 2.3.1.76

Esterification and hydrolysis of vitamin A in the liver of brook trout (Salvelinus fontinalis) and the influence of a coplanar polychlorinated biphenyl

Ndayibagira, A.; Spear, P.A.; Comp. Biochem. Physiol. C 122C, 317-325 (1999)
No PubMed abstract available

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
retinyl esterification: storage of vitamin A
Salvelinus fontinalis
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
not inhibited by 3,3',4,4'-tetrachlorobiphenyl
Salvelinus fontinalis
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.016
-
retinol
-
Salvelinus fontinalis
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
membrane fraction
Salvelinus fontinalis
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acyl-CoA + retinol
Salvelinus fontinalis
-
CoA + retinyl ester
-
Salvelinus fontinalis
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Salvelinus fontinalis
-
fish, brook trout
-
Purification (Commentary)
Commentary
Organism
partial purification by differential centrifugation
Salvelinus fontinalis
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Salvelinus fontinalis
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
activity determined from microsomes
Salvelinus fontinalis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acyl-CoA + retinol
-
487497
Salvelinus fontinalis
CoA + retinyl ester
-
487497
Salvelinus fontinalis
?
palmitoyl-CoA + retinol
-
487497
Salvelinus fontinalis
CoA + retinylpalmitate
-
487497
Salvelinus fontinalis
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
12
-
assay at
Salvelinus fontinalis
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.8
-
maximal activity
Salvelinus fontinalis
pH Range
pH Minimum
pH Maximum
Commentary
Organism
3
11
decreasing activity below pH 5
Salvelinus fontinalis
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
6
11
activity is decreased below
Salvelinus fontinalis
7.8
-
Tris-HCl buffer
Salvelinus fontinalis
Application (protein specific)
Application
Commentary
Organism
medicine
retinyl esterification: storage of vitamin A
Salvelinus fontinalis
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
not inhibited by 3,3',4,4'-tetrachlorobiphenyl
Salvelinus fontinalis
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.016
-
retinol
-
Salvelinus fontinalis
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
membrane fraction
Salvelinus fontinalis
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acyl-CoA + retinol
Salvelinus fontinalis
-
CoA + retinyl ester
-
Salvelinus fontinalis
?
Purification (Commentary) (protein specific)
Commentary
Organism
partial purification by differential centrifugation
Salvelinus fontinalis
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Salvelinus fontinalis
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
activity determined from microsomes
Salvelinus fontinalis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acyl-CoA + retinol
-
487497
Salvelinus fontinalis
CoA + retinyl ester
-
487497
Salvelinus fontinalis
?
palmitoyl-CoA + retinol
-
487497
Salvelinus fontinalis
CoA + retinylpalmitate
-
487497
Salvelinus fontinalis
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
12
-
assay at
Salvelinus fontinalis
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.8
-
maximal activity
Salvelinus fontinalis
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
3
11
decreasing activity below pH 5
Salvelinus fontinalis
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
6
11
activity is decreased below
Salvelinus fontinalis
7.8
-
Tris-HCl buffer
Salvelinus fontinalis
Other publictions for EC 2.3.1.76
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
704611
Shih
Retinol esterification by DGAT ...
Mus musculus
J. Biol. Chem.
284
4292-4299
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
672075
Muniz
11-cis-Acyl-CoA:retinol O-acyl ...
Gallus gallus
Biochemistry
45
12265-12273
2006
1
-
-
-
-
-
1
1
1
-
-
2
-
2
-
-
1
-
-
3
2
-
4
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
1
-
-
2
-
-
-
1
-
3
2
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
658662
Kaschula
Acyl CoA:retinol acyltransfera ...
Bos taurus, Homo sapiens
Exp. Eye Res.
82
111-121
2005
-
-
2
-
-
-
3
7
3
-
-
4
-
4
-
-
-
1
-
5
-
-
7
-
2
-
-
-
2
-
-
-
2
-
1
-
-
2
-
-
-
-
1
3
2
7
3
-
-
4
-
-
-
-
-
5
-
-
7
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
659670
Yen
A human skin multifunctional O ...
Homo sapiens
J. Lipid Res.
46
2388-2397
2005
-
-
1
-
-
-
-
-
1
1
-
2
-
2
-
-
-
-
-
6
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
6
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
672340
Orland
Acyl coenzyme A dependent reti ...
Homo sapiens
Biochim. Biophys. Acta
1737
76-82
2005
-
-
1
-
-
-
1
2
1
-
-
1
-
1
-
-
-
-
-
1
2
-
3
-
1
-
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
1
1
1
2
1
-
-
1
-
-
-
-
-
1
2
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
675260
Yen
The triacylglycerol synthesis ...
Mus musculus
J. Lipid Res.
46
1502-1511
2005
-
-
1
-
1
-
-
-
1
-
-
3
-
2
-
-
-
-
-
4
1
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
4
1
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
487496
Jurukovski
Reduced lecithin:retinol acyl ...
Homo sapiens
Biochim. Biophys. Acta
1436
479-490
1999
1
1
-
-
-
-
-
-
1
-
-
1
-
1
-
-
1
-
-
2
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
2
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
487497
Ndayibagira
-
Esterification and hydrolysis ...
Salvelinus fontinalis
Comp. Biochem. Physiol. C
122C
317-325
1999
-
1
-
-
-
-
1
1
1
-
-
1
-
1
-
-
1
-
-
1
1
-
2
-
1
-
-
-
1
1
2
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
1
-
-
1
-
-
-
1
-
1
1
-
2
-
1
-
-
-
1
1
2
-
-
-
-
-
-
-
487494
Nilsson
2,3,7,8-Tetrachlorodibenzo-p-d ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Environ. Toxicol. Pharmacol.
2
17-23
1996
-
-
-
-
-
-
1
-
1
-
-
2
-
162
-
-
1
-
-
2
1
-
4
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
2
-
-
-
1
-
2
1
-
4
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
487495
Ross
Radiation inactivation analysi ...
Rattus norvegicus
J. Lipid Res.
34
1201-1207
1993
-
1
-
-
-
-
-
-
1
-
-
1
-
2
-
-
1
-
-
2
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
2
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
487489
Ball
Acyl coenzyme A-dependent reti ...
Rattus norvegicus
Methods Enzymol.
189
446-449
1990
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
1
-
-
1
1
1
2
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
1
1
2
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
487490
Ross
Measurement of acyl coenzyme A ...
Rattus norvegicus
Methods Enzymol.
189
442-445
1990
-
-
-
-
-
-
1
-
1
-
-
1
-
1
-
-
1
-
-
1
1
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
1
-
1
1
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
487491
Saari
Acyl-CoA:retinol acyltransfera ...
Bos taurus
Methods Enzymol.
190
156-163
1990
-
1
-
-
-
-
-
-
1
-
-
1
-
2
-
-
1
-
-
2
1
1
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
2
1
1
3
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
487493
MacDonald
Assay of lecithin-retinol acyl ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Methods Enzymol.
189
450-459
1990
-
1
-
-
-
-
2
-
1
-
-
2
-
162
-
-
1
-
-
1
1
1
4
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
-
1
-
1
1
1
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
487492
Chaudhary
Some properties and subcellula ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Biochim. Biophys. Acta
917
24-32
1987
2
1
-
-
-
-
5
-
1
-
-
2
-
162
-
-
1
-
-
1
1
-
8
-
-
-
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
5
-
-
1
-
-
2
-
-
-
1
-
1
1
-
8
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
487488
Ross
Retinol esterification by rat ...
Felis silvestris, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
J. Biol. Chem.
257
2453-2459
1982
2
-
-
-
-
-
5
-
2
-
-
2
-
165
-
-
2
-
-
2
2
1
13
-
1
-
-
-
1
1
2
-
-
-
-
2
-
-
-
-
-
-
-
5
-
-
2
-
-
2
-
-
-
2
-
2
2
1
13
-
1
-
-
-
1
1
2
-
-
-
-
-
-
-