Cloned (Comment) | Organism |
---|---|
residues 30-626 expressed as His-tag fusion protein in Escherichia coli | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
M564G and F565A mutant enzymes crystallized by sitting-drop vapor diffusion method | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
F565A | used for crystallization, only minor effect on protein structure, increased activity with acetyl-CoA | Mus musculus |
M564A | used for crystallization, decreased activity with acetyl-CoA and butyryl-CoA | Mus musculus |
M564G | used for crystallization, dramatic changes in protein structure, decreased activity with acetyl-CoA and butyryl-CoA, strongly increased activity with hexanoyl-CoA | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + carnitine | Mus musculus | modulates acetyl-CoA and CoA availability for a wide range of acyl-transfer reactions, involved in fatty acid metabolism | CoA + O-acetylcarnitine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme using His-tag | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + carnitine | - |
Mus musculus | CoA + O-acetylcarnitine | - |
r | |
acetyl-CoA + carnitine | modulates acetyl-CoA and CoA availability for a wide range of acyl-transfer reactions, involved in fatty acid metabolism | Mus musculus | CoA + O-acetylcarnitine | - |
r | |
butyryl-CoA + carnitine | - |
Mus musculus | CoA + O-butyrylcarnitine | - |
r |
Subunits | Comment | Organism |
---|---|---|
monomer | wild type and mutant enzymes | Mus musculus |