Literature summary for 2.3.1.67 extracted from

Egea, L.; Gimenez, R.; Lucia, D.; Modolell, I.; Badia, J.; Baldoma, L.; Aguilar, J.
Increased production of the ether-lipid platelet-activating factor in intestinal epithelial cells infected by Salmonella enteritidis (2008), Biochim. Biophys. Acta, 1781, 270-276.

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Activating Compound

Activating Compound	Comment	Organism	Structure
calcium calmodulin-dependent protein kinase	-	Homo sapiens
mitogen-activated protein p38	MAP kinase p38	Homo sapiens
additional information	activated by a phosphorylation mechanism	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA	Homo sapiens	lyso-PAF, lyso-platelet-activating factor	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA	PAF, platelet-activating factor	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
cell extracts are prepared	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA	lyso-PAF, lyso-platelet-activating factor	Homo sapiens	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA	PAF, platelet-activating factor	?

Synonyms

Synonyms	Comment	Organism
acetyl-coenzymeA:lysoPAF acetyltransferase	-	Homo sapiens
lysoPAF-AT	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	activity assay	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.9	-	activity assay	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
acetyl-CoA	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	lysoPAF-AT shows a significant activation after 1-h infection with a maximum activity at 2-h infection with Salmonella enteritidis	up

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Release 2023.1 (January 2023)