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Literature summary for 2.3.1.67 extracted from

  • Kihara, Y.; Yanagida, K.; Masago, K.; Kita, Y.; Hishikawa, D.; Shindou, H.; Ishii, S.; Shimizu, T.
    Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-Lyso-PAFAT axis (2008), J. Immunol., 181, 5008-5014.
    View publication on PubMed
Search for more literature for 2.3.1.67

Application

Application Comment Organism
medicine metabolic role in inflammatory disorders using experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS) Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + lyso-platelet-activating factor Mus musculus
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 platelet-activating factor + CoA
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Mus musculus Q8BYI6 mouse; female mice, 8 weeks old, induced with experimental allergic encephalomyelitis (EAE), induction phase, acute phase, and chronic phase, C57BL/6 genetic background
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Source Tissue

Source Tissue Comment Organism Textmining
central nervous system primary cultured cells of Mus musculus
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microglia mRNA and protein expressed in Mus musculus
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microglia mRNA transcript and protein are predominatly expressed in experimental allergic encephalomyelitis (EAE) mice Mus musculus
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spinal cord experimental allergic encephalomyelitis (EAE) mice, after 12d, 19d, and 34d removed Mus musculus
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spinal cord enzymatic activity and mRNA transcripts are elevated in experimental allergic encephalomyelitis (EAE) mice Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 transcript level and enzyme activity elevated in spinal cord of experimental allergic encephalomyelitis (EAE) mice, correlation with disease severity, accumulation of platelet-activating factor dependent on the group IVA cytosolic PLA2/LysoPAFAT present in infiltrating macrophages and activated microglia Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + lyso-platelet-activating factor
-
 Mus musculus platelet-activating factor + CoA
-
 ?
acetyl-CoA + lyso-platelet-activating factor metabolic processing of platelet-activating factor (PAF) in naive and experimental allergic encephalomyelitis (EAE) mice Mus musculus platelet-activating factor + CoA
-
 ?

Synonyms

Synonyms Comment Organism
acetyl-CoA:lysoPAF acetyltransferase
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 Mus musculus
lyso-PAF acetyltransferase
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 Mus musculus
lysoPAFAT
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 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

General Information

General Information Comment Organism
physiological function activities of phospholipase A2 and acetyl-CoA:lyso-PAF acetyltransferase (LysoPAFAT) are elevated in the spinal cord of experimental allergic encephalomyelitis (EAE) mice, an animal model for multiple sclerosis, compared with those of naive mice and correlate with disease severity Mus musculus