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Literature summary for 2.3.1.67 extracted from

  • Shindou, H.; Hishikawa, D.; Nakanishi, H.; Harayama, T.; Ishii, S.; Taguchi, R.; Shimizu, T.
    A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells: cloning and characterization of acetyl-CoA:lyso-PAF acetyltransferase (2007), J. Biol. Chem., 282, 6532-6539.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome microsomal protein with three putative membrane-spanning domains Mus musculus
-
-
microsome microsomal protein with three putative membrane-spanning domains Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF ?
-
?
additional information Homo sapiens enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7L5N7
-
-
Mus musculus Q8BYI6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + lyso-platelet-activating factor
-
Mus musculus platelet-activating factor + CoA
-
?
acetyl-CoA + lyso-platelet-activating factor
-
Homo sapiens platelet-activating factor + CoA
-
?
additional information enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF Mus musculus ?
-
?
additional information enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
acetyl-CoA:lyso-PAF acetyltransferase
-
Mus musculus
acetyl-CoA:lyso-PAF acetyltransferase
-
Homo sapiens
lpafat1
-
Homo sapiens
lyso-PAF acetyltransferase:LPC acyltransferase 1
-
Mus musculus
lyso-PAF acetyltransferase:LPC acyltransferase 1
-
Homo sapiens
mLysoPAFAT/LPCAT2
-
Mus musculus