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Literature summary for 2.3.1.67 extracted from
- Biosynthesis of paf-acether. XI. Regulation of acetyltransferase by enzyme-substrate imbalance (1988), Biochim. Biophys. Acta, 963, 288-294.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| A23187 | - |
Homo sapiens |  |
General Stability
| General Stability | Organism |
|---|---|
| 1-alkyl-sn-glycero-3-phosphocholine at low concentration and lysophosphatidylcholine stabilizes microsomal preparation | Homo sapiens |
| dithiothreitol, 1 mM stabilizes microsomal preparation | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine | irreversible inhibition dependent of both 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine and enzyme concentration | Homo sapiens | |
| 1-O-alkyl-sn-glycero-3-phosphocholine | inhibition at high concentrations due to its detergent effect | Homo sapiens | |
| lysophosphatidylcholine | inhibition at high concentrations due to its detergent effect | Homo sapiens | |
| phenylmethylsulfonyl fluoride | 30% inhibition at 50 mM | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neutrophil | polymorphonuclear, ionophore A23187 stimulates | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
influence of phospholipids on specific activity at 37°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 1-hexadecyl-2-lyso-sn-glycero-3-phosphocholine | 40% higher activity respect to the C18 analogue | Homo sapiens | CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine | - |
? | |
| acetyl-CoA + 1-octadecyl-2-lyso-sn-glycero-3-phosphocholine | - |
Homo sapiens | CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine | - |
? | |
| acetyl-CoA + acetyl-phosphatidylcholine | - |
Homo sapiens | ? | - |
? | |
| acetyl-CoA + lyso-phosphatidylcholine | - |
Homo sapiens | CoA + 2-acetyl-1-acylphosphatidylcholine | - |
? | |
| acetyl-CoA + lyso-phosphatidylethanolamine | - |
Homo sapiens | CoA + 2-acetyl-1-acyl-phosphatidylethanolamine | - |
? | |
| acetyl-CoA + phosphatidylcholine | - |
Homo sapiens | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
85% loss of activity after 2 h, 35% loss of activity after 2 h in the presence of DTT and 1-alkyl-2-lyso-sn-glycero-3-phosphate, microsomal preparation | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
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