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Literature summary for 2.3.1.6 extracted from

  • de Freitas, R.M.
    Lipoic acid increases hippocampal choline acetyltransferase and acetylcholinesterase activities and improvement memory in epileptic rats (2010), Neurochem. Res., 35, 162-170.
    View publication on PubMed
Search for more literature for 2.3.1.6

Activating Compound

Activating Compound Comment Organism Structure
lipoic acid lipoic acid and pilocarpine together increase enzyme activity in the hippocampus of healthy and epileptic rats, lipoic acid alone does not alter hippocampal ChAT activity. Lipoic acid protects rats against pilocarpine-induced seizures and eliminates lethality, overview Rattus norvegicus
pilocarpine lipoic acid and pilocarpine together increase enzyme activity in the hippocampus of healthy and epileptic rats, lipoic acid alone does not alter hippocampal ChAT activity. Lipoic acid protects rats against pilocarpine-induced seizures and eliminates lethality, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
pilocarpine decreases the enzyme activity in the hippocampus, lipoic acid protects, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + choline Rattus norvegicus
-
 CoA + O-acetylcholine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + choline
-
 Rattus norvegicus CoA + O-acetylcholine
-
 ?

Synonyms

Synonyms Comment Organism
ChAT
-
 Rattus norvegicus
choline acetyltransferase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Rattus norvegicus