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Literature summary for 2.3.1.6 extracted from

  • Matsuo, A.; Bellier, J.P.; Hisano, T.; Aimi, Y.; Yasuhara, O.; Tooyama, I.; Saito, N.; Kimura, H.
    Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation (2005), Neurochem. Int., 46, 423-433.
    View publication on PubMed
Search for more literature for 2.3.1.6

Cloned(Commentary)

Cloned (Comment) Organism
expressed as GFP fusion protein in HEK293 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm pChAT and cChAT Rattus norvegicus 5737
-
nucleus cChAT but not pChAT, pChAT found in nucleus only after treatment with leptomycin B Rattus norvegicus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
49000
-
 pChAT Rattus norvegicus
69000
-
 cChAT Rattus norvegicus
76000
-
 pChAT with GFP as fusion protein Rattus norvegicus
96000
-
 cChAT with GFP as fusion protein Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + choline Rattus norvegicus synthesis of the neurotransmitter acetylcholine acetylcholine + CoA
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron pChAT predominantly in peripheral neurons Rattus norvegicus
-
placenta
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + choline
-
 Rattus norvegicus acetylcholine + CoA
-
 r
acetyl-CoA + choline synthesis of the neurotransmitter acetylcholine Rattus norvegicus acetylcholine + CoA
-
 r

Synonyms

Synonyms Comment Organism
cChAT common choline O-acetyltransferase Rattus norvegicus
pChAT peripheral choline O-acetyltransferase, predominantly found in peripheral neurons Rattus norvegicus