BRENDA - Enzyme Database
show all sequences of 2.3.1.59

Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria

Benveniste, R.; Davies, J.; Proc. Natl. Acad. Sci. USA 70, 2276-2280 (1973)

Data extracted from this reference:

Application
Application
Commentary
Organism
analysis
rapid analysis of antibiotic concentration in serum
Streptomyces kanamyceticus
analysis
rapid analysis of antibiotic concentration in serum
Streptomyces spectabilis
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Streptomyces spectabilis
5737
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Streptomyces spectabilis
modification of antibiotics
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Streptomyces kanamyceticus
-
-
-
Streptomyces spectabilis
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
acetyl-CoA + gentamicin C1
-
487272
Streptomyces spectabilis
CoA + N2'-acetylgentamicin C1
-
-
-
?
acetyl-CoA + gentamicin C1a
-
487272
Streptomyces kanamyceticus
CoA + N2'-acetylgentamicin C1a
-
-
-
?
acetyl-CoA + gentamicin C1a
acetylates 2'-amino group of hexose moiety
487272
Streptomyces spectabilis
CoA + N2'-acetylgentamicin C1a
-
487272
Streptomyces spectabilis
?
acetyl-CoA + kanamycin B
-
487272
Streptomyces spectabilis
CoA + N2-acetylkanamycin B
-
-
-
?
acetyl-CoA + kanamycin C
-
487272
Streptomyces spectabilis
CoA + N2'-acetylkanamycin C
-
-
-
?
acetyl-CoA + paromomycin
-
487272
Streptomyces spectabilis
CoA + N2'-acetylparomomycin
-
-
-
?
additional information
-
487272
Streptomyces spectabilis
?
-
-
-
-
additional information
modification of antibiotics
487272
Streptomyces spectabilis
?
-
-
-
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.3
-
-
Streptomyces spectabilis
Application (protein specific)
Application
Commentary
Organism
analysis
rapid analysis of antibiotic concentration in serum
Streptomyces kanamyceticus
analysis
rapid analysis of antibiotic concentration in serum
Streptomyces spectabilis
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Streptomyces spectabilis
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Streptomyces spectabilis
modification of antibiotics
?
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
acetyl-CoA + gentamicin C1
-
487272
Streptomyces spectabilis
CoA + N2'-acetylgentamicin C1
-
-
-
?
acetyl-CoA + gentamicin C1a
-
487272
Streptomyces kanamyceticus
CoA + N2'-acetylgentamicin C1a
-
-
-
?
acetyl-CoA + gentamicin C1a
acetylates 2'-amino group of hexose moiety
487272
Streptomyces spectabilis
CoA + N2'-acetylgentamicin C1a
-
487272
Streptomyces spectabilis
?
acetyl-CoA + kanamycin B
-
487272
Streptomyces spectabilis
CoA + N2-acetylkanamycin B
-
-
-
?
acetyl-CoA + kanamycin C
-
487272
Streptomyces spectabilis
CoA + N2'-acetylkanamycin C
-
-
-
?
acetyl-CoA + paromomycin
-
487272
Streptomyces spectabilis
CoA + N2'-acetylparomomycin
-
-
-
?
additional information
-
487272
Streptomyces spectabilis
?
-
-
-
-
additional information
modification of antibiotics
487272
Streptomyces spectabilis
?
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.3
-
-
Streptomyces spectabilis
Other publictions for EC 2.3.1.59
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
487274
Payie
Characterization of gentamicin ...
Providencia stuartii
J. Bacteriol.
179
4106-4114
1997
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
487275
Clarke
The prevalence of gentamicin 2 ...
no activity in Morganella morganii, no activity in Proteus myxofaciens, no activity in Proteus vulgaris, no activity in Providencia heimbachae, no activity in Providencia rustigianii, Proteus penneri, Providencia rettgeri, Providencia stuartii, Providencia stuartii PR50
FEMS Microbiol. Lett.
145
201-207
1996
-
-
-
-
-
-
-
-
-
-
-
2
-
14
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
487276
Payie
The role of O-acetylation in t ...
Providencia stuartii
Microb. Drug Resist.
2
135-140
1996
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
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1
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
487273
Chevereau
Aminoglycoside resistance in b ...
Providencia sp. 164, Providencia sp.
Biochemistry
13
598-603
1974
-
-
-
-
-
1
-
-
-
-
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-
-
3
-
-
-
-
-
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-
-
19
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
1
-
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-
-
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-
-
-
-
-
-
19
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
487272
Benveniste
Aminoglycoside antibiotic-inac ...
Streptomyces kanamyceticus, Streptomyces spectabilis
Proc. Natl. Acad. Sci. USA
70
2276-2280
1973
-
2
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
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8
-
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-
-
-
1
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2
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1
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1
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8
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1
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