Literature summary for 2.3.1.57 extracted from

Keinanen, T.; Hyvonen, T.; Vepsalainen, J.; Alhonen, L.; Khomutov, A.; Janne, J.
Stable analogues of coenzyme-substrate complex of spermidine/spermine-N 1-acetyltransferase reaction. Synthesis and interaction with the enzyme (2014), Russ. J. Bioorg. Chem., 40, 155-161.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	conjugates of symmetrical polyamines spermine , 1,12-diamino-4,9-diazadodecane and of nor-spermidine, 1,7-diamino-4-azaheptane, with coenzyme A, mimicking intermediate the coenzyme-substrate complex, are synthesized to inhibit the enzyme, overview	Homo sapiens
O-(11-amino-3,8-diaza-1-undecyl)oxime S-(2-oxopropyl)-CoA	-	Homo sapiens
O-(11-amino-3,8-diaza-1-undecyl)oxime S-(2-oxopropyl)-D-pantetheine	-	Homo sapiens
O-(6-amino-3-aza-1-hexyl)oxime S-(2-oxopropyl)-CoA	-	Homo sapiens
O-(6-amino-3-aza-1-hexyl)oxime S-(2-oxopropyl)-D-pantetheine	-	Homo sapiens
O-(7-amino-3-aza-1-heptyl)oxime S-(2-oxopropyl)-CoA	-	Homo sapiens
O-(7-amino-3-aza-1-heptyl)oxime S-(2-oxopropyl)-D-pantetheine	-	Homo sapiens
O-(7-amino-4-aza-1-heptyl)oxime S-(2-oxopropyl)-CoA	-	Homo sapiens
O-(7-amino-4-aza-1-heptyl)oxime S-(2-oxopropyl)-D-pantetheine	-	Homo sapiens
S-(2-oxopropyl)-CoA	-	Homo sapiens
S-(2-oxopropyl)-D-pantetheine	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3 acetyl-CoA + 2 spermine	Homo sapiens	-	3 CoA + N1-acetylspermine + N1,N12-diacetylspermine	-	?
3 acetyl-CoA + spermidine	Homo sapiens	-	3 CoA + N1,N4,N8-triacetylspermidine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P21673	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3 acetyl-CoA + 2 spermine	-	Homo sapiens	3 CoA + N1-acetylspermine + N1,N12-diacetylspermine	-	?
3 acetyl-CoA + spermidine	-	Homo sapiens	3 CoA + N1,N4,N8-triacetylspermidine	-	?

Synonyms

Synonyms	Comment	Organism
spermidine/spermine-N 1-acetyltransferase	-	Homo sapiens
SSAT	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
acetyl-CoA	-	Homo sapiens

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Release 2023.1 (January 2023)