Literature summary for 2.3.1.57 extracted from

Lee, S.B.; Park, J.H.; Folk, J.E.; Deck, J.A.; Pegg, A.E.; Sokabe, M.; Fraser, C.S.; Park, M.H.
Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1) (2011), Biochem. J., 433, 205-213.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	synthetic peptide IVEMSTSKTGK50HGHAK modeled on the sequence of amino acids surrounding the hypusine residue K50, 50% inhibition of eIF5A acetylation at 0.05 mM	Homo sapiens
spermidine	0.005 mM, strong inhibition of eIF5A acetylation	Homo sapiens
spermine	0.05 mM, strong inhibition of eIF5A acetylation	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + eIF5A	Homo sapiens	-	CoA + acytyl-eIF5A	selective acetylation of the hypusine and/or deoxyhypusine residue of translation initiation factor eIF5A, resulting in loss of eIF5A activity. Hypusine or deoxyhypusine, as the free amino acid, do not act as a substrate for isoform SSAT1	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P21673	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + eIF5A	-	Homo sapiens	CoA + acytyl-eIF5A	selective acetylation of the hypusine and/or deoxyhypusine residue of translation initiation factor eIF5A, resulting in loss of eIF5A activity. Hypusine or deoxyhypusine, as the free amino acid, do not act as a substrate for isoform SSAT1	?

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Release 2023.1 (January 2023)