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Literature summary for 2.3.1.57 extracted from

  • Zahedi, K.; Barone, S.L.; Xu, J.; Steinbergs, N.; Schuster, R.; Lentsch, A.B.; Amlal, H.; Wang, J.; Casero, R.A.; Soleimani, M.
    Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury (2012), Am. J. Physiol. Gastrointest. Liver Physiol., 303, G546-G560.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine compared with wild-typet mice, the enzyme-deficient mice subjected to endotoxic acute kidney injury have less severe kidney damage as indicated by better preservation of kidney function. Animals treated with MDL72527, an inhibitor of both polyamine oxidase and spermine oxidase, show significant protection against endotoxin-induced acute kidney injury. Increased polyamine catabolism may contribute to kidney damage through generation of by-products of polyamine oxidation Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
SSAT
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus SSAT mRNA expression peaks at threefold 24 h following lipopolysaccharide injection and returns to background levels by 48 h. The activity of SSAT correlates with its mRNA levels up

General Information

General Information Comment Organism
physiological function compared with wild-typet mice, the enzyme-deficient mice subjected to endotoxic acute kidney injury have less severe kidney damage as indicated by better preservation of kidney function. Animals treated with MDL72527, an inhibitor of both polyamine oxidase and spermine oxidase, show significant protection against endotoxin-induced acute kidney injury. Increased polyamine catabolism may contribute to kidney damage through generation of by-products of polyamine oxidation Mus musculus