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Literature summary for 2.3.1.57 extracted from

  • Marverti, G.; Ligabue, A.; Guerrieri, D.; Paglietti, G.; Piras, S.; Costi, M.P.; Farina, D.; Frassineti, C.; Monti, M.G.; Moruzzi, M.S.
    Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines (2009), Gynecol. Oncol., 117, 202-210.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
additional information folate cycle inhibitors, with quinoxaline moieties 3-methyl-7-trifluoromethyl-2(R)-[3,4,5-trimethoxyanilino]-quinoxaline or 3-piperazinilmethyl-2[4(oxymethyl)-phenoxy]quinoxaline, affect the enzyme, simultaneous drug combination or quinoxaline pre-treatment synergistically increases SSAT expression, depletes polyamines, increases reactive oxygen species production, and produces synergistic tumor cell killing in both cell lines, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens simultaneous drug combination or quinoxaline pre-treatment synergistically increases SSAT expression, depletes polyamines, increases reactive oxygen species production, and produces synergistic tumor cell killing in both cell lines, overview. Cisplatin-resistant human ovarian cell line, A2780/CP cells, cannot be induced by spermidine analogues, in contrast to the sensitive counterpart A2780 ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
colon carcinoma cell
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 Homo sapiens
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OV-2008 cell
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 Homo sapiens
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ovarian cancer cell epithelial Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information simultaneous drug combination or quinoxaline pre-treatment synergistically increases SSAT expression, depletes polyamines, increases reactive oxygen species production, and produces synergistic tumor cell killing in both cell lines, overview. Cisplatin-resistant human ovarian cell line, A2780/CP cells, cannot be induced by spermidine analogues, in contrast to the sensitive counterpart A2780 Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
spermidine/spermine N1-acetyltransferase
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 Homo sapiens
SSAT
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 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens induction of SSAT gene expression by combined quinoxalines and spermidine analogue treatment, overview. The cDDP-resistant human ovarian cell line, A2780/CP, shows defective expression and inducibility of SSAT by Spm analogues, when compared to the sensitive counterpart A2780 up