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Literature summary for 2.3.1.57 extracted from

  • Uimari, A.; Keinaenen, T.A.; Karppinen, A.; Woster, P.; Uimari, P.; Jaenne, J.; Alhonen, L.
    Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts (2009), Biochem. J., 422, 101-109.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.57

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of EGFP-tagged SSAT in SSAT-deficient mouse fetal fibroblasts in cytosol and nucleus. The presence of SSAT-EGFP leads to a 9fold induction in SSAT activity in transfected untreated cells when compared with the cells transfected with EGFP Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of SSAT-deficient fetal fibroblasts transiently expressing an SSAT-EGFP construct Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
nucleus
-
 Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast fetal Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus
0.0000035
-
 recombinant EGFP-tagged SSAT in cells Mus musculus
0.0012
-
 recombinant EGFP-tagged SSAT in cells in presence of N'-ethyl-N''-[(cyclopropyl)-methy]-4,8-diazaundecane Mus musculus
0.0058
-
 recombinant EGFP-tagged SSAT in cells in presence of N'-ethyl-N''-[(cycloheptyl)methy]-4,8-diazaundecane Mus musculus
0.0106
-
 recombinant EGFP-tagged SSAT in cells in presence of N',N''-diethylnorspermine Mus musculus

Synonyms

Synonyms Comment Organism
SAT1
-
 Mus musculus
spermidine/spermine N1-acetyltransferase
-
 Mus musculus
SSAT
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus N',N''-diethylnorspermine, N'-ethyl-N''-[(cyclopropyl)-methy]-4,8-diazaundecane, and N'-ethyl-N''-[(cycloheptyl)methy]-4,8-diazaundecane treatments lead to high, moderate, or low induction of SSAT activity, respectively up

General Information

General Information Comment Organism
metabolism SSAT is the key enzyme in the catabolism of polyamines, and is turned over rapidly with only a low amount of enzyme present in the cell. Analogue-affected regulation of SSAT expression occurrs, mainly, after transcription. Depleted intracellular spermidine and spermine levels inversely correlate with the SSAT activity Mus musculus