Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.57 extracted from

  • Alhonen, L.; Karppinen, A.; Uusi-Oukari, M.; Vujcic, S.; Korhonen, V.P.; Halmekytö, M.; Kramer, D.L.; Hines, R.; Jänne, J.; Porter, C.W.
    Correlation of polyamine and growth responses to N1,N11-diethylnorspermine in primary fetal fibroblasts derived from transgenic mice overexpressing spermidine/spermine N1-acetyltransferase (1998), J. Biol. Chem., 273, 1964-1969.
    View publication on PubMed
Search for more literature for 2.3.1.57

Activating Compound

Activating Compound Comment Organism Structure
additional information N1,N11-diethylnorspermine induces SSAT activity by post-mRNA regulation Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
full-length cDNA is cloned and expressed in Escherichia coli M15, generation of a transgenic mouse line systemically overexpressing SSAT, overexpression alters polyamine pools and sensitize cells to the antiproliferative activity of N1,N11-diethylnorspermine Mus musculus

General Stability

General Stability Organism
N1,N11-diethylnorspermine stabilizes Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus SSAT catalyzes together with polyamine oxidase the back-conversion of spermine to spermidine and the latter to putrescine, a function lowering polyamine pools by facilitating their catabolism and excretion ?
-
 ?
additional information Mus musculus polyamine catabolic enzyme ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 transgenic mouse line overexpressing SSAT
-

Source Tissue

Source Tissue Comment Organism Textmining
fetus primary fetal fibroblasts Mus musculus
-
fibroblast primary fetal fibroblasts Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
 Mus musculus CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine
-
 Mus musculus CoA + N1-acetylspermine
-
 ?
additional information SSAT catalyzes together with polyamine oxidase the back-conversion of spermine to spermidine and the latter to putrescine, a function lowering polyamine pools by facilitating their catabolism and excretion Mus musculus ?
-
 ?
additional information polyamine catabolic enzyme Mus musculus ?
-
 ?