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Literature summary for 2.3.1.56 extracted from

  • Bartsch, H.; Dworkin, C.; Miller, E.C.; Miller, J.A.
    Formation of electrophilic N-acetoxyarylamines in cytosols from rat mammary gland and other tissues by transacetylation from the carcinogen N-hydroxy-4-acetylaminobiphenyl (1973), Biochim. Biophys. Acta, 304, 42-55.
    View publication on PubMed
Search for more literature for 2.3.1.56

Activating Compound

Activating Compound Comment Organism Structure
reduced pyridine nucleotides mammary gland Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide
-
 Rattus norvegicus
N-ethylmaleimide
-
 Rattus norvegicus
NaF weak Rattus norvegicus
PCMB
-
 Rattus norvegicus
puromycin weak Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl Rattus norvegicus transfers the N-acetyl group of some aromatic acethydroxamic acids to the O-position of some aromatic hydroxylamines N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
mammary gland
-
 Rattus norvegicus
-
additional information no activity in rat ear duct sebaceous gland, lung, dog urinary bladder mucosa Rattus norvegicus
-
muscle low activity Rattus norvegicus
-
small intestine mucosa
-
 Rattus norvegicus
-
spleen low activity Rattus norvegicus
-

Storage Stability

Storage Stability Organism
0-4°C, about 30% loss of activity after 6 h Rattus norvegicus
0-4°C, inactivation after 18 h Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl i.e. N-hydroxy-N2-fluorenylacetamide, not mammary gland enzyme Rattus norvegicus N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
 ?
N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene
-
 Rattus norvegicus N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene
-
 ?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl Rattus norvegicus N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
 ?
N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl transfers the N-acetyl group of some aromatic acethydroxamic acids to the O-position of some aromatic hydroxylamines Rattus norvegicus N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 liver Rattus norvegicus
7.5
-
 mammary gland Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.8 8.2 about 80% of maximal activity at pH 6.8 and pH 8.2 Rattus norvegicus