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Literature summary for 2.3.1.54 extracted from

  • Al-Bayati, F.A.; Kahya, H.F.; Damianou, A.; Shafeeq, S.; Kuipers, O.P.; Andrew, P.W.; Yesilkaya, H.
    Pneumococcal galactose catabolism is controlled by multiple regulators acting on pyruvate formate lyase (2017), Sci. Rep., 7, 43587 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.54

Cloned(Commentary)

Cloned (Comment) Organism
gene pflB, ligands CcpA, GlnR, and GntR interact with the putative promoters of pflA and pflB, CcpA and GlnR bind to promoters containing cre sites Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CoA + pyruvate Streptococcus pneumoniae
-
 acetyl-CoA + formate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae A0A0H2ZQE4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CoA + pyruvate
-
 Streptococcus pneumoniae acetyl-CoA + formate
-
 ?

Synonyms

Synonyms Comment Organism
PFL
-
 Streptococcus pneumoniae
PflB
-
 Streptococcus pneumoniae
pyruvate formate lyase
-
 Streptococcus pneumoniae

Expression

Organism Comment Expression
Streptococcus pneumoniae analysis of the transcriptional regulation of gene pflB, overview additional information

General Information

General Information Comment Organism
malfunction mutation of either pflB, which codes for PFL, or pflA, which codes for pyruvate formate lyase activating enzyme, results in abrogation of mixed acid fermentation on galactose, and leads to a decrease in pneumococcal virulence Streptococcus pneumoniae
metabolism multiple regulators control the transcription of pflA and pflB, some of these regulators are induced by galactose, their control over pflA and pflB is influenced by sodium formate, they exert regulatory influence on each other, and are required for pneumococcal colonization and virulence. Transcriptional profile of mutant DELTApflB compared to the wild-type D39 strain, expression of seven genes annotated as transcriptional regulators is either significantly up or downregulated in the mutant, overview. CcpA, GlnR, and GntR interact with the putative promoters of pflA and pflB, impact of formate on binding affinity of CcpA and GlnR Streptococcus pneumoniae
physiological function pyruvate formate lyase (PFL), converting pyruvate to formate and acetyl-CoA, is the key enzyme for mixed acid fermentation. Active pyruvate formate lyase (PFL) synthesis is finely tuned, and feedback inhibition and activation involving the pyruvate formate lyase activating enzyme, are detected, analysis of the transcriptional regulation of gene pflA, overview. The pyruvate formate lyase activating enzyme (PFL-AE) is responsible for posttranslational activation of inactive PFL Streptococcus pneumoniae