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Literature summary for 2.3.1.54 extracted from

  • Wagner, A.F.V.; Frey, M.; Neugebauer, F.A.; Schäfer, W.; Knappe, J.
    The free radical in pyruvate formate-lyase is located on glycine-734 (1992), Proc. Natl. Acad. Sci. USA, 89, 996-1000.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
 2 * 85000, homodimer, SDS-PAGE Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + CoA Escherichia coli key enzyme of the glucose fermentation route in anaerobically growing cells acetyl-CoA + formate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Oxidation Stability

Oxidation Stability Organism
obligate anaerobic enzyme, enzymatic conversion by a unique homolytic mechanism that involves a free radical harbored in the protein structure, protein based organic free radical is essential for catalysis, oxygen destruction of the protein radical Escherichia coli

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA
-
 Escherichia coli acetyl-CoA + formate
-
 ?
pyruvate + CoA key enzyme of the glucose fermentation route in anaerobically growing cells Escherichia coli acetyl-CoA + formate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 85000, homodimer, SDS-PAGE Escherichia coli