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Literature summary for 2.3.1.51 extracted from

  • Agarwal, A.K.; Tunison, K.; Dalal, J.S.; Nagamma, S.S.; Hamra, F.K.; Sankella, S.; Shao, X.; Auchus, R.J.; Garg, A.
    Metabolic, reproductive, and neurologic abnormalities in Agpat1-null mice (2017), Endocrinology, 158, 3954-3973 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate Mus musculus
-
 CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AGPAT1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient mice develop widespread disturbances of metabolism, sperm development, and neurologic function resulting from disrupted phospholipid homeostasis. Enzyme-deficient mice have reduced body weight, total body fat, and plasma leptin level and show features of epilepsy. Neonatal enzyme-deficient mice have minor alterations in lipid synthesis and reduced plasma glucose levels. Enzyme-deficient males and females mice have reproductive abnormalities Mus musculus