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Literature summary for 2.3.1.51 extracted from
- A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids (2014), Biochem. Biophys. Res. Commun., 443, 718-724.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in CHO-K1 cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 37000 | - |
x * 37000, SDS-PAGE | Mus musculus |
| 43800 | - |
x * 43800, calculated from amino acid sequence | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + 1-acyl-sn-glycerol 3-phosphate | Mus musculus | the enzyme has high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA | CoA + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q8K4X7 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Mus musculus | - |
| brain | highest expression | Mus musculus | - |
| colon | - |
Mus musculus | - |
| intestine | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| Neuro-2a cell | - |
Mus musculus | - |
| stomach | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | - |
Mus musculus | CoA + 1-oleoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-sn-glycerol 3-phosphate | - |
? | |
| (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-CoA + 1-palmitoyl-sn-glycerol 3-phosphate | highest activity | Mus musculus | CoA + palmitoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-sn-glycerol 3-phosphate | - |
? | |
| (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-CoA + 1-stearoyl-sn-glycerol 3-phosphate | - |
Mus musculus | CoA + 1-stearoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-sn-glycerol 3-phosphate | - |
? | |
| acyl-CoA + 1-acyl-sn-glycerol 3-phosphate | the enzyme has high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA | Mus musculus | CoA + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 37000, SDS-PAGE | Mus musculus |
| ? | x * 43800, calculated from amino acid sequence | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AGPAT4 | formerly | Mus musculus |
| LPAAT4 | - |
Mus musculus |
| LPAATdelta | formerly | Mus musculus |
| lysophosphatidic acid acyltransferase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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