Application | Comment | Organism |
---|---|---|
medicine | the role of isoforms AGPAT1 or AGPAT2 in liver lipogenesis is minimal and accumulation of liver fat is primarily a consequence of insulin resistance and loss of adipose tissue in Agpat2 -/- mice | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression via recombinant adenoviruses in Agpat2 -/- mice | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | both isoforms AGPAT1 and AGPAT2 | Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15120 | - |
- |
Homo sapiens | Q99943 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
linoleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | linoleoyl-CoA is second best acyl-CoA substrate | Homo sapiens | CoA + 1-oleoyl-2-linoleoyl-sn-glycerol 3-phosphate | - |
? | |
additional information | no substrates: acyl-CoA with fatty acids shorter than C14:0 or longer than C20:0, whether saturated or unsaturated | Homo sapiens | ? | - |
? | |
additional information | no substrates: acyl-CoA with fatty acids shorter than C14:0 or longer than C20:0, whether saturated or unsaturated. Isoform AGPAT2 is rather restrictive in using 1-oleoyl-sn-glycerol 3-phosphate as acceptor substrate | Homo sapiens | ? | - |
? | |
oleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | both substrates are preferred | Homo sapiens | CoA + 1,2-dioleoyl-sn-glycerol 3-phosphate | - |
? | |
pentadecanoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | 50% of the rate with oleoyl-CoA and linoleoyl-CoA | Homo sapiens | CoA + 1-oleoyl-2-pentadecanoyl-sn-glycerol 3-phosphate | - |
? | |
pentadecanoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | rate is similar to oleoyl-CoA and linoleoyl-CoA | Homo sapiens | CoA + 1-oleoyl-2-pentadecanoyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AGPAT1 | - |
Homo sapiens |
AGPAT2 | - |
Homo sapiens |