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Literature summary for 2.3.1.51 extracted from
- Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function (2009), J. Cell Biol., 186, 211-218.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| stable functional expression of GFP-tagged LPAAT3 in HeLa cells and in Rattus norvegicus hepatocytes with localization in the Golgi membranes | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | overexpression of LPAAT3 in HeLa cells significantly inhibits the formation of Golgi membrane tubules in vivo and in vitro. Anterograde and retrograde protein trafficking is slower in cells overexpressing LPAAT3 and accelerated in cells with expression reduced by siRNA, LPAAT3 knockdown leads to Golgi fragmentation, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CI-976 | inhibits LPAAT and stimulates Golgi tubules | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi membrane | integral enzyme | Homo sapiens | 139 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | LPAAT3 regulates Golgi membrane tubule formation, trafficking, and structure by altering phospholipids and lysophospholipids. LPAAT3 alters ERGIC-53 distribution, a p58 receptor which is a lectin receptor that traffics between the cis-Golgi and the endoplasmic reticulum | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | LPAAT3 regulates Golgi membrane tubule formation, trafficking, and structure by altering phospholipids and lysophospholipids. LPAAT3 alters ERGIC-53 distribution, a p58 receptor which is a lectin receptor that traffics between the cis-Golgi and the endoplasmic reticulum | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AGPAT3 | - |
Homo sapiens |
| LPAAT3 | - |
Homo sapiens |
| lysophosphatidic acid acyltransferase 3 | - |
Homo sapiens |
| lysophosphatidic acidspecific acyltransferase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | LPAAT3 regulates Golgi complex structure and function, overview | Homo sapiens |
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Release 2023.1 (January 2023)
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