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Literature summary for 2.3.1.51 extracted from

  • Haque, W.; Garg, A.; Agarwal, A.K.
    Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy (2005), Biochem. Biophys. Res. Commun., 327, 446-453.
    View publication on PubMed
Search for more literature for 2.3.1.51

Cloned(Commentary)

Cloned (Comment) Organism
expression in Chineses hamster ovary cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
140delF 34.8% of wild-type activity Homo sapiens
221delGT 5% of wild-type activity Homo sapiens
252delMRT 3.2% of wild-type activity Homo sapiens
A239V 90% of wild-type activity Homo sapiens
D180fsX251 7.7% of wild-type activity Homo sapiens
G136R 40.3% of wild-type activity Homo sapiens
L228P 23.7% of wild-type activity Homo sapiens
R68X 14.2% of wild-type activity Homo sapiens
V167fsX228 14.9% of wild-type activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate Homo sapiens reduction in AGPAT2 activity underlies the loss of adipose tissue in congenital generalized lipodystrophy CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate reduction in AGPAT2 activity underlies the loss of adipose tissue in congenital generalized lipodystrophy Homo sapiens CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
arachidonoyl-CoA + 1-oleoyl-glycerol-3-phosphate
-
 Homo sapiens 1-oleoyl-2-arachidonoyl-glycerol-3-phosphate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
1-acylglycerol-3-phosphate-O-acyltransferase 2
-
 Homo sapiens
AGPAT2
-
 Homo sapiens