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Literature summary for 2.3.1.50 extracted from

  • Hirata, Y.; Yamamori, N.; Kono, N.; Lee, H.C.; Inoue, T.; Arai, H.
    Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein (2013), Genes Cells, 18, 397-409.
    View publication on PubMed
Search for more literature for 2.3.1.50

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of ssSPTa, tagged with EGFP at its N-terminus, in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of small subunit of serine palmitoyltransferase a, ssSPTa Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
membrane in mitochondria-associated membrane Homo sapiens 16020
-
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the small subunit of serine palmitoyltransferase a (ssSPTa) as an lysophosphatidylinositol acyltransferase 1 (LPIAT1)-interacting protein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q969W0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the small subunit of serine palmitoyltransferase a (ssSPTa) as an lysophosphatidylinositol acyltransferase 1 (LPIAT1)-interacting protein Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
serine palmitoyltransferase a
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of small subunit of serine palmitoyltransferase a decreases the an lysophosphatidylinositol acyltransferase 1-dependent incorporation of exogenous aracidonic acid into phosphatidylinositol but does not affect the in vitro enzyme activity of an lysophosphatidylinositol acyltransferase 1 in the microsomal fraction. ssSPTa knockdown decreases the protein level of LPIAT1 in the crude mitochondrial fraction but not in total homogenate or the microsomal fraction Homo sapiens
metabolism the small subunit of serine palmitoyltransferase a (ssSPTa) as an lysophosphatidylinositol acyltransferase 1 (LPIAT1)-interacting protein and colocalizes with LPIAT1 in cultured mammalian cells Homo sapiens
physiological function the small subunit of serine palmitoyltransferase a (ssSPTa) plays a role in fatty acid remodeling of phosphatidyl inositol, probably by facilitating the MAM localization oflysophosphatidylinositol acyltransferase 1, LPIAT1 Homo sapiens