Cloned (Comment) | Organism |
---|---|
subunit 2 expressed in HEK293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G382V | subunit 2, activity affected, naturally occuring mutation, hereditary sensory and autonomic neuropathy type I, expression in HEK293 cells increases concentration of neurotoxic 1-deoxysphinganine | Homo sapiens |
I504F | subunit 2, activity affected, naturally occuring mutation, hereditary sensory and autonomic neuropathy type I, expression in HEK293 cells increases concentration of neurotoxic 1-deoxysphinganine | Homo sapiens |
V359M | subunit 2, activity affected, naturally occuring mutation, hereditary sensory and autonomic neuropathy type I, expression in HEK293 cells increases concentration of neurotoxic 1-deoxysphinganine | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
myriocin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15270 and Q9NUV7 | subunit 2 and 3 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + palmitoyl-CoA | - |
Homo sapiens | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
serine palmitoyltransferase | - |
Homo sapiens |