Cloned (Comment) | Organism |
---|---|
subunit LCB1, DNA and amino acid sequence determination and analysis | Nicotiana benthamiana |
subunit LCB2 | Nicotiana benthamiana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | reduced sphingolipid synthesis resulting from suppression of NbLCB2 expression interferes with normal leaf morphogenesis. NbLCB2 overexpression causes a cell death phenotype in Nicotiana benthamiana leaves. Downregulation of the genes encoding for the enzyme subunits compromises pathogen resistance against Pseudomonas cichorii | Nicotiana benthamiana |
additional information | the phenotype of NbLCB1-silenced plants is almost the same as the control except for a slight downward curling of leaf edges in NbLCB1-silenced plants. Downregulation of the genes encoding for the enzyme subunits compromises pathogen resistance against Pseudomonas cichorii | Nicotiana benthamiana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
myriocin | inhibits the enzyme and inhibits defense response against a nonhost pathogen; inhibits the enzyme and inhibits defense response against a nonhost pathogen | Nicotiana benthamiana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Nicotiana benthamiana | B3Y000 | subunit LCB2; two genes encoding the LCB2 and LCB1 subunits of the enzyme | - |
Nicotiana benthamiana | B3Y9H2 | subunit LCB1 fragment; two genes encoding the LCB2 and LCB1 subunits of the enzyme | - |
Synonyms | Comment | Organism |
---|---|---|
serine palmitoyltransferase | - |
Nicotiana benthamiana |
SPT | - |
Nicotiana benthamiana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | the pyridoxal 5'-phosphate binding site is required for the LCB2 gene cell death inducing function | Nicotiana benthamiana |
Organism | Comment | Expression |
---|---|---|
Nicotiana benthamiana | Pseudomonas cichorii infection induces expression of subunit LCB2 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is required for resistance against pathogen Pseudomonas cichorii. The gene for the LCB2 subunit of SPT is a potent inducer of hypersensitive response-like cell death involving pyridoxal 5'-phosphate | Nicotiana benthamiana |