Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.50 extracted from

  • Granado, M.H.; Gangoiti, P.; Ouro, A.; Arana, L.; Gomez-Munoz, A.
    Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages (2009), Biochim. Biophys. Acta, 1791, 263-272.
    View publication on PubMed
Search for more literature for 2.3.1.50

Inhibitors

Inhibitors Comment Organism Structure
ceramide 1-phosphate from bovine brain, inhibits the enzyme and blocks apoptosis in alveolar macrophages, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Rattus norvegicus
-
 CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage alveolar Rattus norvegicus
-
NR-8383 cell
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 enzyme activity and ceramide synthesis in macrophages, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine
-
 Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Subunits

Subunits Comment Organism
dimer two SPT subunits, SPT1 and SPT2 Rattus norvegicus

Synonyms

Synonyms Comment Organism
serine palmitoyltransferase
-
 Rattus norvegicus
SPT
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus

General Information

General Information Comment Organism
metabolism SPT is the key regulator enzyme in the ceramide de novo biosynthesis pathway Rattus norvegicus
physiological function the enzyme is required for ceramide synthesis as key regulatory enzyme of this pathway, major mechanism for ceramide generation in NR8383 macrophages is stimulation of their de novo synthesis Rattus norvegicus