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Literature summary for 2.3.1.50 extracted from

  • Chen, M.; Han, G.; Dietrich, C.R.; Dunn, T.M.; Cahoon, E.B.
    The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase (2006), Plant Cell, 18, 3576-3593.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
subunits LCB1 and LCB2, phylogenetic tree, expression of Arabidopsis thaliana subunit LCB1 rescues the sphingolipid long-chain base auxotrophy of Saccharomyces cerevisiae SPT mutants when coexpressed with Arabidopsis thaliana LCB2 Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information homozygous T-DNA insertion mutants for At LCB1 are not recoverable, but viability is restored by complementation with the wild-type At LCB1 gene, T-DNA disruption of AtLCB1 results in embryo lethality, partial RNAi suppression of At LCB1 expression is accompanied by a marked reduction in plant size that resulted primarily from reduced cell expansion, while the sphingolipid content remains unaltered, overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Arabidopsis thaliana
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Arabidopsis thaliana step in the sphingolipid biosynthetic pathway, overview CoA + 3-dehydro-D-sphinganine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9LSZ9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
anther mature Arabidopsis thaliana
-
cotyledon
-
Arabidopsis thaliana
-
flower
-
Arabidopsis thaliana
-
leaf
-
Arabidopsis thaliana
-
additional information ubiquitous expression of subunits LCB1 and LCB2 in the plant Arabidopsis thaliana
-
root
-
Arabidopsis thaliana
-
seed mature Arabidopsis thaliana
-
stem
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine
-
Arabidopsis thaliana CoA + 3-dehydro-D-sphinganine + CO2
-
?
palmitoyl-CoA + L-serine step in the sphingolipid biosynthetic pathway, overview Arabidopsis thaliana CoA + 3-dehydro-D-sphinganine + CO2
-
?

Subunits

Subunits Comment Organism
dimer SPT is a heterodimer that consists of LCB1 and LCB2 subunits, which together form the active site of this enzyme Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
serine palmitoyltransferase
-
Arabidopsis thaliana
SPT
-
Arabidopsis thaliana