Cloned (Comment) | Organism |
---|---|
subunits LCB1 and LCB2, phylogenetic tree, expression of Arabidopsis thaliana subunit LCB1 rescues the sphingolipid long-chain base auxotrophy of Saccharomyces cerevisiae SPT mutants when coexpressed with Arabidopsis thaliana LCB2 | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | homozygous T-DNA insertion mutants for At LCB1 are not recoverable, but viability is restored by complementation with the wild-type At LCB1 gene, T-DNA disruption of AtLCB1 results in embryo lethality, partial RNAi suppression of At LCB1 expression is accompanied by a marked reduction in plant size that resulted primarily from reduced cell expansion, while the sphingolipid content remains unaltered, overview | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Arabidopsis thaliana | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-serine | Arabidopsis thaliana | step in the sphingolipid biosynthetic pathway, overview | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q9LSZ9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
anther | mature | Arabidopsis thaliana | - |
cotyledon | - |
Arabidopsis thaliana | - |
flower | - |
Arabidopsis thaliana | - |
leaf | - |
Arabidopsis thaliana | - |
additional information | ubiquitous expression of subunits LCB1 and LCB2 in the plant | Arabidopsis thaliana | - |
root | - |
Arabidopsis thaliana | - |
seed | mature | Arabidopsis thaliana | - |
stem | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-serine | - |
Arabidopsis thaliana | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + L-serine | step in the sphingolipid biosynthetic pathway, overview | Arabidopsis thaliana | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | SPT is a heterodimer that consists of LCB1 and LCB2 subunits, which together form the active site of this enzyme | Arabidopsis thaliana |
Synonyms | Comment | Organism |
---|---|---|
serine palmitoyltransferase | - |
Arabidopsis thaliana |
SPT | - |
Arabidopsis thaliana |