Application | Comment | Organism |
---|---|---|
medicine | ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the developmental role of Nat2 is investigated using transgenic Nat2 knockout/lacZ knockin mice: The transgene is bred onto an A/J background and offspring are scored for developmental defects at weaning. After backcross generation eight, an ocular defect, ranging from cataract to microphthalmia and anophthalmia, is recorded among offspring of backcross and intercross pairs. While Nat2-/- mice are described as overtly aphenotypic, the presence of a Nat2 null allele in one or both parents can result in ocular defects. These ocular phenotypes and their association with Nat2 genotype indicate that the Nat2 locus may be responsible for the described microphthalmic phenotype | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | - |
Mus musculus | - |
neural tube | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
arylamine N-acetyltransferase 2 | - |
Mus musculus |
NAT2 | - |
Mus musculus |