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Literature summary for 2.3.1.5 extracted from

  • Fukino, K.; Sasaki, Y.; Hirai, S.; Nakamura, T.; Hashimoto, M.; Yamagishi, F.; Ueno, K.
    Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients (2008), J. Toxicol. Sci., 33, 187-195.
    View publication on PubMed

Application

Application Comment Organism
medicine results suggest that care should be taken to prevent the development of isoniazid-induced hepatic disorder in patients who have the NAT2 SA phenotype, a high concentration of rifampicin and who carry the GST M1 null genotype Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information genotypes of drug-metabolizing enzymes (NAT2, CYP2E15*B, CYP2E1*6, Glutathione-S-transferase (GST) M1 and GST T1) involved in isoniazid metabolism and the serum concentrations of isoniazid and its metabolites in 129 tuberculosis patients are investigated. Acetylating pathway of isoniazid to acetyl isoniazid tends to shift to the hydrolytic pathway generating hydrazine with the increase of mutant alleles in NAT2 gene Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
arylamine N-acetyltransferase 2
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Homo sapiens
NAT2
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Homo sapiens