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Literature summary for 2.3.1.5 extracted from

  • Liu, L.; Von Vett, A.; Zhang, N.; Walters, K.J.; Wagner, C.R.; Hanna, P.E.
    Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2 (2007), Chem. Res. Toxicol., 20, 1300-1308.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
human wild-type NAT2 is overexpressed as a dihydrofolate reductase fusion protein containing a TEV protease-sensitive linker Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.059
-
p-Aminosalicylic acid
-
Homo sapiens
0.084
-
p-Aminobenzoic acid
-
Homo sapiens
0.109
-
2-Aminofluorene
-
Homo sapiens
0.191
-
4-aminobiphenyl
-
Homo sapiens
0.205
-
4-ethylaniline
-
Homo sapiens
0.28
-
3,5-dimethylaniline
-
Homo sapiens
0.286
-
2-Aminofluorene
-
Homo sapiens
0.352
-
3,4-dimethylaniline
-
Homo sapiens
0.483
-
4-methylaniline
-
Homo sapiens
0.486
-
4-aminobiphenyl
-
Homo sapiens
0.576
-
3-ethylaniline
-
Homo sapiens
0.688
-
3,4-dimethylaniline
-
Homo sapiens
0.742
-
3,5-dimethylaniline
-
Homo sapiens
1.11
-
2,3-dimethylaniline
-
Homo sapiens
1.32
-
3-ethylaniline
-
Homo sapiens
2.06
-
2,4-dimethylaniline
-
Homo sapiens
2.11
-
2-ethylaniline
-
Homo sapiens
2.32
-
2-methylaniline
-
Homo sapiens
2.49
-
aniline
-
Homo sapiens
3.12
-
2,5-dimethylaniline
-
Homo sapiens
3.27
-
4-ethylaniline
-
Homo sapiens
5.03
-
2,4-dimethylaniline
-
Homo sapiens
5.39
-
sulfamethazine
-
Homo sapiens
5.39
-
p-Aminosalicylic acid
-
Homo sapiens
5.53
-
2,3-dimethylaniline
-
Homo sapiens
6.73
-
2,5-dimethylaniline
-
Homo sapiens
7.18
-
2-methylaniline
-
Homo sapiens
112
-
aniline
-
Homo sapiens
118
-
4-methylaniline
-
Homo sapiens
152
-
p-Aminobenzoic acid
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
SDS-PAGE Homo sapiens
33840
-
mass spectrometry Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by using chromatographic purification. Yield: 2.8 mg of homogeneous NAT2 from 2 L of cell culture Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 2,3-dimethylaniline
-
Homo sapiens CoA + N-acetyl-2,3-dimethylaniline
-
?
acetyl-CoA + 2,4-dimethylaniline
-
Homo sapiens CoA + N-acetyl-2,4-dimethylaniline
-
?
acetyl-CoA + 2,5-dimethylaniline
-
Homo sapiens CoA + N-acetyl-2,5-dimethylaniline
-
?
acetyl-CoA + 2-aminofluorene
-
Homo sapiens CoA + N-acetyl-2-aminofluorene
-
?
acetyl-CoA + 2-ethylaniline
-
Homo sapiens CoA + N-acetyl-2-ethylaniline
-
?
acetyl-CoA + 2-methylaniline
-
Homo sapiens CoA + N-acetyl-2-methylaniline
-
?
acetyl-CoA + 3,4-dimethylaniline
-
Homo sapiens CoA + N-acetyl-3,4-dimethylaniline
-
?
acetyl-CoA + 3,5-dimethylaniline
-
Homo sapiens CoA + N-acetyl-3,5-dimethylaniline
-
?
acetyl-CoA + 3-ethylaniline
-
Homo sapiens CoA + N-acetyl-3-ethylaniline
-
?
acetyl-CoA + 4-aminobiphenyl
-
Homo sapiens CoA + N-acetyl-4-aminobiphenyl
-
?
acetyl-CoA + 4-ethylaniline
-
Homo sapiens CoA + N-acetyl-4-ethylaniline
-
?
acetyl-CoA + 4-methylaniline
-
Homo sapiens CoA + N-acetyl-4-methylaniline
-
?
acetyl-CoA + aniline
-
Homo sapiens CoA + N-acetyl-aniline
-
?
acetyl-CoA + p-aminobenzoic acid
-
Homo sapiens CoA + N-acetyl-4-aminobenzoic acid
-
?
acetyl-CoA + p-aminosalicylic acid
-
Homo sapiens CoA + N-acetyl-4-aminosalicylic acid
-
?
acetyl-CoA + sulfamethazine
-
Homo sapiens CoA + N-acetyl-sulfamethazine
-
?

Synonyms

Synonyms Comment Organism
arylamine N-acetyltransferase 1
-
Homo sapiens
NAT1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.7
-
2,5-dimethylaniline
-
Homo sapiens
12
-
2-methylaniline
-
Homo sapiens
27
-
p-Aminosalicylic acid
-
Homo sapiens
27
-
2,3-dimethylaniline
-
Homo sapiens
38
-
p-Aminobenzoic acid
-
Homo sapiens
61
-
2-ethylaniline
-
Homo sapiens
67
-
2,4-dimethylaniline
-
Homo sapiens
111
-
2-methylaniline
-
Homo sapiens
243
-
4-aminobiphenyl
-
Homo sapiens
256
-
4-aminobiphenyl
-
Homo sapiens
256
-
2,3-dimethylaniline
-
Homo sapiens
281
-
aniline
-
Homo sapiens
298
-
p-Aminobenzoic acid
-
Homo sapiens
303
-
4-methylaniline
-
Homo sapiens
308
-
3,5-dimethylaniline
-
Homo sapiens
310
-
3-ethylaniline
-
Homo sapiens
313
-
2,5-dimethylaniline
-
Homo sapiens
387
-
sulfamethazine
-
Homo sapiens
430
-
4-ethylaniline
-
Homo sapiens
449
-
2-Aminofluorene
-
Homo sapiens
461
-
3,4-dimethylaniline
-
Homo sapiens
591
-
p-Aminosalicylic acid
-
Homo sapiens
661
-
2,4-dimethylaniline
-
Homo sapiens
700
-
4-ethylaniline
-
Homo sapiens
711
-
aniline
-
Homo sapiens
759
-
2-Aminofluorene
-
Homo sapiens
800
-
3,4-dimethylaniline
-
Homo sapiens
1220
-
3,5-dimethylaniline
-
Homo sapiens
1600
-
4-methylaniline
-
Homo sapiens
1960
-
3-ethylaniline
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Homo sapiens