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Literature summary for 2.3.1.5 extracted from

  • Summerscales, J.E.; Josephy, P.D.
    Human acetyl CoA:arylamine N-acetyltransferase variants generated by random mutagenesis (2004), Mol. Pharmacol., 65, 220-226.
    View publication on PubMed
Search for more literature for 2.3.1.5

Protein Variants

Protein Variants Comment Organism
A54V activity with 2-aminofluorene is about 10% of the wild-type activity Homo sapiens
D251G activity with 2-aminofluorene is about 15% of the wild-type activity Homo sapiens
F202L activity with 2-aminofluorene is about 20% of the wild-type activity Homo sapiens
I238T activity with 2-aminofluorene is about 30% of the wild-type activity, the KM-value for 2-aminofluorene is 1.3fold higher than the wild-type value Homo sapiens
K185N activity with 2-aminofluorene is about 35% of the wild-type activity, the KM-value for 2-aminofluorene is 1.5fold higher than the wild-type value Homo sapiens
L181A activity with 2-aminofluorene is about 80% of the wild-type activity Homo sapiens
L194R activity with 2-aminofluorene is about 30% of the wild-type activity Homo sapiens
L40H activity with 2-aminofluorene is about 5% of the wild-type activity Homo sapiens
M205V activity with 2-aminofluorene is about 40% of the wild-type activity Homo sapiens
N172I activity with 2-aminofluorene is about 20% of the wild-type activity, the KM-value for 2-aminofluorene is 3.6fold higher than the wild-type value Homo sapiens
N245I activity with 2-aminofluorene is about 85% of the wild-type activity, the KM-value for 2-aminofluorene is 1.3fold higher than the wild-type value Homo sapiens
P96L activity with 2-aminofluorene is slightly higher than wild-type activity Homo sapiens
Q226R activity with 2-aminofluorene is about 15% of the wild-type activity Homo sapiens
T198A activity with 2-aminofluorene is about 50% of the wild-type activity Homo sapiens
T207S activity with 2-aminofluorene is slightly higher than wild-type activity Homo sapiens
V146A activity with 2-aminofluorene is about 50% of the wild-type activity Homo sapiens
W77R activity with 2-aminofluorene is about 25% of the wild-type activity, the KM-value for 2-aminofluorene is 1.3fold higher than the wild-type value Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.238
-
 2-Aminofluorene wild-type enzyme Homo sapiens
0.298
-
 2-Aminofluorene mutant enzyme I238T Homo sapiens
0.301
-
 2-Aminofluorene mutant enzyme 245I Homo sapiens
0.304
-
 2-Aminofluorene mutant enzyme W77R Homo sapiens
0.367
-
 2-Aminofluorene mutant enzyme K185N Homo sapiens
0.857
-
 2-Aminofluorene mutant enzyme N172I Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 2-aminofluorene
-
 Homo sapiens CoA + 2-acetylaminofluorene
-
 ?

Synonyms

Synonyms Comment Organism
NAT2
-
 Homo sapiens