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Literature summary for 2.3.1.5 extracted from
- Evidence for arylamine N-acetyltransferase activity in Klebsiella pneumoniae (2004), J. Microbiol. Immunol. Infect., 37, 208-215.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | - |
Klebsiella pneumoniae |  |
| iodoacetamide | 50% inhibition at 0.25 mM, 90% inhibition at 1.0 mM | Klebsiella pneumoniae | |
| Zn2+ | - |
Klebsiella pneumoniae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.42 | - |
4-Aminobenzoate | - |
Klebsiella pneumoniae | |
| 2.92 | - |
2-Aminofluorene | - |
Klebsiella pneumoniae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Klebsiella pneumoniae | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 44900 | - |
x * 44900, SDS-PAGE | Klebsiella pneumoniae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Klebsiella pneumoniae | no expression of NAT2 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella pneumoniae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Klebsiella pneumoniae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 3.506 | - |
- |
Klebsiella pneumoniae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 2-aminofluorene | - |
Klebsiella pneumoniae | CoA + 2-acetylaminofluorene | - |
? | |
| acetyl-CoA + 4-aminobenzoate | - |
Klebsiella pneumoniae | CoA + 4-acetylaminobenzoate | - |
? | |
| additional information | no expression of NAT2 | Klebsiella pneumoniae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 44900, SDS-PAGE | Klebsiella pneumoniae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NAT1 | - |
Klebsiella pneumoniae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
activity with 2-aminofluorene and 4-aminobenzoate | Klebsiella pneumoniae |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 4 | 60 | the enzyme is active in the range | Klebsiella pneumoniae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
activity with 2-aminofluorene and 4-aminobenzoate | Klebsiella pneumoniae |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 9.5 | about 25% of maximal activity pH 5.0 and pH 9.5 with 2-aminofluorene as substrate, about 65% of maximal activity at pH 5.0 and at pH 9.5 with p-aminobenzoate as substrate | Klebsiella pneumoniae |
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Release 2023.1 (January 2023)
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